Molecular tools for the construction of peptide-based materials

B.E.I. Ramakers, J.C.M. van Hest, D.W.P.M. Löwik

Research output: Contribution to journalReview articlepeer-review

93 Citations (Scopus)


Proteins and peptides are fundamental components of living systems where they play crucial roles at both functional and structural level. The versatile biological properties of these molecules make them interesting building blocks for the construction of bio-active and biocompatible materials. A variety of molecular tools can be used to fashion the peptides necessary for the assembly of these materials. In this tutorial review we shall describe five of the main techniques, namely solid phase peptide synthesis, native chemical ligation, Staudinger ligation, NCA polymerisation, and genetic engineering, that have been used to great effect for the construction of a host of peptide-based materials. This journal is

Original languageEnglish
Pages (from-to)2743-2756
Number of pages14
JournalChemical Society Reviews
Issue number8
Publication statusPublished - 21 Apr 2014
Externally publishedYes


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