Molecular dynamics study of vesicle deformation mechanisms

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Abstract

Lipid bilayer membranes are known to form various structures like large sheets or vesicles. When both bilayer leaflets have equal composition, membranes preferentially form flat sheets or spherical vesicles. However, vesicles with a wide variety of shapes, including ellipsoids, discoids, pear-shaped, cup-shaped and budded vesicles, have been shown experimentally. Such shapes were predicted theoretically from energy minimization of continuous sheets as well. We show, using coarse-grained molecular dynamics simulations, how relatively small asymmetry in composition between the two leaflets may result in spontaneously curved bilayers and all these vesicle shapes. Three types of bilayer asymmetry are considered. Firstly, the situation where the headgroup-solvent interaction and thus the lipid packing alters due to a change in pH or ion-concentration of the vesicle interior/exterior (A). Secondly, where asymmetry arises from phase separation of two lipid types (B). And thirdly, where asymmetry arises from growth of one of the bilayer leaflets by incorporation of additional lipids from the solvent (C).
Original languageEnglish
Title of host publicationAbstracts of the 52nd Annual Meeting and 16th International Biophysics Congress (2-6 February, 2008) Long Beach, United States
Place of PublicationBethesda, Md.
PublisherBiophysical Society
Pages344-344
DOIs
Publication statusPublished - 2008
Event52th Biophysical Society Annual Meeting, Februari 2-6, 2008, Long Beach, California, United States - Long Beach, United States
Duration: 2 Feb 20086 Feb 2008

Publication series

NameBiophysical Journal
Volume94
ISSN (Print)0006-3495

Conference

Conference52th Biophysical Society Annual Meeting, Februari 2-6, 2008, Long Beach, California, United States
CountryUnited States
CityLong Beach
Period2/02/086/02/08

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lipids
asymmetry
molecular dynamics
membranes
ion concentration
ellipsoids
optimization
simulation
interactions
energy

Cite this

Markvoort, A. J., Spijker, P., Santen, van, R. A., & Hilbers, P. A. J. (2008). Molecular dynamics study of vesicle deformation mechanisms. In Abstracts of the 52nd Annual Meeting and 16th International Biophysics Congress (2-6 February, 2008) Long Beach, United States (pp. 344-344). (Biophysical Journal; Vol. 94). Bethesda, Md.: Biophysical Society. https://doi.org/10.1016/S0006-3495(08)79058-1
Markvoort, A.J. ; Spijker, P. ; Santen, van, R.A. ; Hilbers, P.A.J. / Molecular dynamics study of vesicle deformation mechanisms. Abstracts of the 52nd Annual Meeting and 16th International Biophysics Congress (2-6 February, 2008) Long Beach, United States. Bethesda, Md. : Biophysical Society, 2008. pp. 344-344 (Biophysical Journal).
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Markvoort, AJ, Spijker, P, Santen, van, RA & Hilbers, PAJ 2008, Molecular dynamics study of vesicle deformation mechanisms. in Abstracts of the 52nd Annual Meeting and 16th International Biophysics Congress (2-6 February, 2008) Long Beach, United States. Biophysical Journal, vol. 94, Biophysical Society, Bethesda, Md., pp. 344-344, 52th Biophysical Society Annual Meeting, Februari 2-6, 2008, Long Beach, California, United States, Long Beach, United States, 2/02/08. https://doi.org/10.1016/S0006-3495(08)79058-1

Molecular dynamics study of vesicle deformation mechanisms. / Markvoort, A.J.; Spijker, P.; Santen, van, R.A.; Hilbers, P.A.J.

Abstracts of the 52nd Annual Meeting and 16th International Biophysics Congress (2-6 February, 2008) Long Beach, United States. Bethesda, Md. : Biophysical Society, 2008. p. 344-344 (Biophysical Journal; Vol. 94).

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Markvoort AJ, Spijker P, Santen, van RA, Hilbers PAJ. Molecular dynamics study of vesicle deformation mechanisms. In Abstracts of the 52nd Annual Meeting and 16th International Biophysics Congress (2-6 February, 2008) Long Beach, United States. Bethesda, Md.: Biophysical Society. 2008. p. 344-344. (Biophysical Journal). https://doi.org/10.1016/S0006-3495(08)79058-1