Modular, lightweight, wireless potentiostat-on-a-disc for electrochemical detection in centrifugal microfluidics

Sriram Thoppe Rajendran (Corresponding author), Ermes Scarano, Max H. Bergkamp, Alessandro M. Capria, Chung Hsiang Cheng, Kuldeep Sanger, Giorgio Ferrari, Line H. Nielsen, En Te Hwu, Kinga Zór (Corresponding author), Anja Boisen

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Interfacing electrochemical sensors in a lab-on-a-disc (LoD) system with a potentiostat is often tedious and challenging. We here present the first multichannel, modular, lightweight, and wirelessly powered, custom-built potentiostat-on-a-disc (PoD) for centrifugal microfluidic applications. The developed potentiostat is in the form factor of a typical digital video disc (DVD) and weighs only 127 g. The design of the potentiostat facilitates easy and robust interfacing with the electrodes in the LoD system, while enabling real-time electrochemical detection during rotation. The device can perform different electroanalytical techniques such as cyclic voltammetry, square wave voltammetry, and amperometry while being controlled by custom-made software. Measurements were conducted with and without rotation using both in-house fabricated and commercial electrodes. The performance of the PoD was in good agreement with the results obtained using a commercial potentiostat with a measured current resolution of 200 pA. As a proof of concept, we performed a real-time release study of an electrochemically active compound from microdevices used for drug delivery.

Original languageEnglish
Pages (from-to)11620-11628
Number of pages9
JournalAnalytical Chemistry
Volume91
Issue number18
DOIs
Publication statusPublished - 17 Sep 2019

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