TY - JOUR
T1 - Modular, lightweight, wireless potentiostat-on-a-disc for electrochemical detection in centrifugal microfluidics
AU - Rajendran, Sriram Thoppe
AU - Scarano, Ermes
AU - Bergkamp, Max H.
AU - Capria, Alessandro M.
AU - Cheng, Chung Hsiang
AU - Sanger, Kuldeep
AU - Ferrari, Giorgio
AU - Nielsen, Line H.
AU - Hwu, En Te
AU - Zór, Kinga
AU - Boisen, Anja
PY - 2019/9/17
Y1 - 2019/9/17
N2 - Interfacing electrochemical sensors in a lab-on-a-disc (LoD) system with a potentiostat is often tedious and challenging. We here present the first multichannel, modular, lightweight, and wirelessly powered, custom-built potentiostat-on-a-disc (PoD) for centrifugal microfluidic applications. The developed potentiostat is in the form factor of a typical digital video disc (DVD) and weighs only 127 g. The design of the potentiostat facilitates easy and robust interfacing with the electrodes in the LoD system, while enabling real-time electrochemical detection during rotation. The device can perform different electroanalytical techniques such as cyclic voltammetry, square wave voltammetry, and amperometry while being controlled by custom-made software. Measurements were conducted with and without rotation using both in-house fabricated and commercial electrodes. The performance of the PoD was in good agreement with the results obtained using a commercial potentiostat with a measured current resolution of 200 pA. As a proof of concept, we performed a real-time release study of an electrochemically active compound from microdevices used for drug delivery.
AB - Interfacing electrochemical sensors in a lab-on-a-disc (LoD) system with a potentiostat is often tedious and challenging. We here present the first multichannel, modular, lightweight, and wirelessly powered, custom-built potentiostat-on-a-disc (PoD) for centrifugal microfluidic applications. The developed potentiostat is in the form factor of a typical digital video disc (DVD) and weighs only 127 g. The design of the potentiostat facilitates easy and robust interfacing with the electrodes in the LoD system, while enabling real-time electrochemical detection during rotation. The device can perform different electroanalytical techniques such as cyclic voltammetry, square wave voltammetry, and amperometry while being controlled by custom-made software. Measurements were conducted with and without rotation using both in-house fabricated and commercial electrodes. The performance of the PoD was in good agreement with the results obtained using a commercial potentiostat with a measured current resolution of 200 pA. As a proof of concept, we performed a real-time release study of an electrochemically active compound from microdevices used for drug delivery.
UR - http://www.scopus.com/inward/record.url?scp=85070899866&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.9b02026
DO - 10.1021/acs.analchem.9b02026
M3 - Article
C2 - 31335122
AN - SCOPUS:85070899866
VL - 91
SP - 11620
EP - 11628
JO - Analytical Chemistry
JF - Analytical Chemistry
SN - 0003-2700
IS - 18
ER -