Abstract
This work is aimed at investigating the influence of thermal damage in the consolidation of bone formation during electrostimulation. Given the complexity of the biological process, we introduce a mathematical model that simplifies the problem into four constitutive elements: the migration of osteoprogenitor cells, the thermal variation, the thermal damage accumulation, and the formation of new bone matrix. Numerical results are in agreement with experimental data, and show that cell density and bone formation are reduced when an electric field higher than 10 V/cm is applied. This reduction is related to imminent cell death by necrosis and apoptosis when the temperature is above a threshold value. The model is suitable to conduct dosimetry studies in other different electrostimulation techniques used to improve bone and soft tissues repair.
| Original language | English |
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| Title of host publication | Proceedings of the 5th International Conference on Electromagnetic Fields, Health and Environment (EHE 2014), 24-26 April 2014, Porto, Portugal |
| Place of Publication | Porto |
| Number of pages | 2 |
| Publication status | Published - 2014 |
| Event | 5th International Conference on Electromagnetic Fields, Health and Environment (EHE 2014), April 24-25, 2014, Porto, Portugal - Porto, Portugal Duration: 24 Apr 2014 → 25 Apr 2014 |
Conference
| Conference | 5th International Conference on Electromagnetic Fields, Health and Environment (EHE 2014), April 24-25, 2014, Porto, Portugal |
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| Abbreviated title | (EHE 2014) |
| Country/Territory | Portugal |
| City | Porto |
| Period | 24/04/14 → 25/04/14 |