Modelling the PCR amplification process by a size-dependent branching process and estimation of the efficiency

N. Lalam, C. Jacob, P. Jagers

Research output: Contribution to journalArticleAcademicpeer-review

35 Citations (Scopus)

Abstract

We propose a stochastic modelling of the PCR amplification process by a size-dependent branching process starting as a supercritical Bienaymé-Galton-Watson transient phase and then having a saturation near-critical size-dependent phase. This model allows us to estimate the probability of replication of a DNA molecule at each cycle of a single PCR trajectory with a very good accuracy.
Original languageEnglish
Pages (from-to)602-615
JournalAdvances in Applied Probability
Volume36
Issue number2
DOIs
Publication statusPublished - 2004

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