The 'hybrid' scenario is an attractive operating scenario for ITER since it combines long plasma duration with the reliability of the reference H-mode regime. We review the recent European modelling effort carried out within the Integrated Scenario Modelling group which aims at (i) understanding the underlying physics of the hybrid regime in ASDEX-Upgrade and JET and (ii) extrapolating them towards ITER. JET and ASDEX-Upgrade hybrid scenarios performed under different experimental conditions have been simulated in an interpretative and predictive way in order to address the current profile dynamics and its link with core confinement, the relative importance of magnetic shear, s, and E × B flow shear on the core turbulence, pedestal stability and H–L transition. The correlation of the improved confinement with an increased s/q at outer radii observed in JET and ASDEX-Upgrade discharges is consistent with the predictions based on the GLF23 model applied in the simulations of the ion and electron kinetic profiles. Projections to ITER hybrid scenarios have been carried out focusing on optimization of the heating/current drive schemes to reach and ultimately control the desired plasma equilibrium using ITER actuators. Firstly, access condition to the hybrid-like q-profiles during the current ramp–up phase has been investigated. Secondly, from the interpreted role of the s/q ratio, ITER hybrid scenario flat-top performance has been optimized through tailoring the q-profile shape and pedestal conditions. EPED predictions of pedestal pressure and width have been used as constraints in the interpretative modelling while the core heat transport is predicted by GLF23. Finally, model-based approach for real-time control of advanced tokamak scenarios has been applied to ITER hybrid regime for simultaneous magnetic and kinetic profile control.