Modeling the pre-invasive breast cancer microenvironment using high-throughput microfluidic cell encapsulation

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Abstract

The majority of breast cancer deaths are caused by metastases to other tissues. Biomechanical changes in the extracellular matrix (ECM) are thought to play a pivotal role in the metastatic process. In order to study this role, models with control over the ECM properties are essential. We report a novel high-throughput microfluidics-based approach to build a physiologically relevant model of pre-invasive breast cancer, capturing the onset of metastasis: invasion of cancer cells from basal into stromal tissue. We use droplet microfluidics to build a heterogeneous tissue, enabling control over tissue size, cell count, and ECM composition and stiffness.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages798-799
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2017
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAs 2017) - Savannah International Trade & Convention Center 1 International Drive Savannah, Georgia 31402 USA, Savannah, United States
Duration: 22 Oct 201726 Oct 2017
Conference number: 21
http://www.microtasconferences.org/microtas2017/

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAs 2017)
Abbreviated titleMicroTAS 2017
CountryUnited States
CitySavannah
Period22/10/1726/10/17
Internet address

Keywords

  • Breast cancer
  • Extracellular matrix
  • Metastasis
  • Microdroplets

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  • Cite this

    Sleeboom, J. J. F., Sahlgren, C. M., & den Toonder, J. M. J. (2017). Modeling the pre-invasive breast cancer microenvironment using high-throughput microfluidic cell encapsulation. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 798-799). Chemical and Biological Microsystems Society.