Modeling the Mechanical Parameters of Glaucoma

Pascal A.M.M. Vroemen, Theo G.M.F. Gorgels, Carroll A.B. Webers, Jan de Boer

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Glaucoma is a major eye disease characterized by a progressive loss of retinal ganglion cells (RGCs). Biomechanical forces as a result of hydrostatic pressure and strain play a role in this disease. Decreasing intraocular pressure is the only available therapy so far, but is not always effective and does not prevent blindness in many cases. There is a need for drugs that protect RGCs from dying in glaucoma; to develop these, we need valid glaucoma and drug screening models. Since in vivo models are unsuitable for screening purposes, we focus on in vitro and ex vivo models in this review. Many groups have studied pressure and strain model systems to mimic glaucoma, to investigate the molecular and cellular events leading to mechanically induced RGC death. Therefore, the focus of this review is on the different mechanical model systems used to mimic the biomechanical forces in glaucoma. Most models use either cell or tissue strain, or fluid- or gas-controlled hydrostatic pressure application and apply it to the relevant cell types such as trabecular meshwork cells, optic nerve head astrocytes, and RGCs, but also to entire eyes. New model systems are warranted to study concepts and test experimental compounds for the development of new drugs to protect vision in glaucoma patients.

Original languageEnglish
Pages (from-to)412-428
Number of pages17
JournalTissue Engineering - Part B: Reviews
Volume25
Issue number5
DOIs
Publication statusPublished - Oct 2019

Keywords

  • biomechanical models
  • glaucoma
  • hydrostatic pressure
  • strain
  • Animals
  • Glaucoma/drug therapy
  • Intraocular Pressure
  • Humans
  • Retinal Ganglion Cells/cytology
  • Drug Evaluation, Preclinical
  • Neuroprotective Agents/pharmacology
  • Disease Models, Animal

Fingerprint Dive into the research topics of 'Modeling the Mechanical Parameters of Glaucoma'. Together they form a unique fingerprint.

Cite this