Modeling the effect of intercalators on the high-force stretching behavior of DNA

K.K. Schakenraad, I. Heller, A. Biebricher, G. Wuite, C. Storm, P. van der Schoot

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Abstract

DNA is structurally and mechanically altered by the binding of intercalator molecules. Intercalation strongly affects the force-extension behavior of DNA, in particular the overstretching transition. We present a statistical model that captures all relevant findings of recent force-extension experiments. Two predictions from our model are presented. The first suggests the existence of a novel hyper-stretching regime in the presence of intercalators and the second, a linear dependence of the overstretching force on intercalator concentration, is verified by re-analyzing available experimental data. Our model pins down the physical principles that govern intercalated DNA mechanics, providing a predictive understanding of its limitations and possibilities.
Original languageEnglish
Article number1512.07039
Pages (from-to)1-5
Number of pages5
JournalarXiv.org, e-Print Archive, Physics
Issue number1512.07039
Publication statusPublished - 22 Dec 2015

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