Modeling patients' methylmalonic acid levels using probabilistic fuzzy systems

Rui Jorge Almeida, Saskia van Loon, Uzay Kaymak, Anna Wilbik, Volkher Scharnhorst, Arjen Kars Boer

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

3 Citations (Scopus)
2 Downloads (Pure)


Vitamin B12 deficiency is a common disorder with severe impacts on hematological and neurological disorders. Identifying vitamin B12 deficiency is not straightforward since blood vitamin B12 levels are not representative for actual vitamin B12 status in tissue. Instead, methylmalonic acid (MMA) levels in the plasma are used as indicators of vitamin B12 deficiency. MMA concentrations increase starting from the early course of vitamin B12 deficiency but they may also be high regardless of vitamin B12 deficiency due to renal failure (measured by eGFR). In this paper we propose the use of probabilistic fuzzy systems (PFS) to explore the relationship between MMA plasma levels with vitamin B12 and kidney function. We propose a PFS model for the analysis of overall MMA properties for all patients and also specific MMA properties for individual patients. We show that this PFS model leads to accurate MMA interval predictions. We further show that the proposed model can be used to assess a change in the eGFR level to a normal eGFR level, and its effect on the patient's MMA distribution.

Original languageEnglish
Title of host publication2017 IEEE International Conference on Fuzzy Systems (FUZZ-IEEE), 9-12 July 2017, Naples, Italy
Place of PublicationPiscataway
PublisherInstitute of Electrical and Electronics Engineers
Number of pages6
ISBN (Electronic)978-1-5090-6034-4
ISBN (Print)978-1-5090-6035-1
Publication statusPublished - 23 Aug 2017
Event2017 IEEE International Conference on Fuzzy Systems (FUZZ 2017) - Naples, Italy
Duration: 9 Jul 201712 Jul 2017


Conference2017 IEEE International Conference on Fuzzy Systems (FUZZ 2017)
Abbreviated titleFUZZ 2017


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