Modeling of NAD+ analogues in horse liver alcohol dehydrogenase

N.A. Beijer, H.M. Buck, L.A.A.E. Sluyterman, E.M. Meijer

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

So far, the interactions of nicotinamide adenine dinucleotide (NAD+) derivatives with dehydrogenases are not very well understood. This hampers the introduction of NAD+ analogues with improved characteristics concerning industrial application. We have developed an AMBER molecular mechanics model in order to obtain insight into the relevant interactions of NAD+ and its analogues with horse liver alcohol dehydrogenase (HLADH). The results show that the reactivity of NAD+ derivatives can be directly related to the coenzyme analogue geometry in the ternary complex.
Original languageEnglish
Pages (from-to)494-500
Number of pages7
JournalAnnals of the New York Academy of Sciences
Volume613
DOIs
Publication statusPublished - 1990

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