Abstract
So far, the interactions of nicotinamide adenine dinucleotide (NAD+) derivatives with dehydrogenases are not very well understood. This hampers the introduction of NAD+ analogues with improved characteristics concerning industrial application. We have developed an AMBER molecular mechanics model in order to obtain insight into the relevant interactions of NAD+ and its analogues with horse liver alcohol dehydrogenase (HLADH). The results show that the reactivity of NAD+ derivatives can be directly related to the coenzyme analogue geometry in the ternary complex.
Original language | English |
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Pages (from-to) | 494-500 |
Number of pages | 7 |
Journal | Annals of the New York Academy of Sciences |
Volume | 613 |
DOIs | |
Publication status | Published - 1990 |