Modeling of intracerebral interictal epileptic discharges : evidence for network interactions

P.P.W. Ossenblok, S.P.L. Meesters, A. Colon, L. Wagner, O.E.M.G. Schijns, P.J. Boon, L.M.J. Florack, A. Fuster

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose:
Stereotactic EEG (SEEG) recordings are considered to be the best choice for preoperative invasive evaluation when the epilepsy of the patient is suspected to originate in deep-sited anatomical structures and standard electro-clinical examinations are not conclusive. The interictal epileptic discharges (IEDs) occurring in these recordings in general are abundant compared to ictal discharges, but difficult to interpret due to
complex underlying network interactions.
Method:
A framework is developed to model the spatiotemporal net-work interactions underlying the IEDs. To identify the highly synchronized neural activity underlying these discharges, the variation in correlation over time of the SEEG signals is related to the occurrence of the IEDs using the general linear model [van Houdt et al., 2012]. Subsequently, it is assessed whether the brain regions that reflect highly synchronized neural activity are either independent or interacting within an epileptic network. Independent component analysis is applied followed by clustering of the spatial distributions of the independent components.
The spatial distributions of the spike clusters are visualized together with the estimated time delays against the patients’ brain anatomy [Meesters et al., 2015].
Results:
The analysis framework was evaluated for five patients who underwent SEEG recordings prior to successful epilepsy surgery. The spatial distribution of the spike cluster that was related to the MRI-visible brain lesions coincided with the seizure onset zone of these patients.
Unraveling of the complex network interactions underlying the IEDs of two more patients without satisfactory surgical outcome indicated that an alternative and plausible resection strategy could have been considered.
Conclusion:
The analysis framework applied to IEDs is considered a valuable additional tool to the current seizure assessment approach, which might lead to a more successful outcome of epilepsy surgery.
Acknowledgement:
This study is part of the DeNeCor-project that has received funding from the ENIAC Joint Undertaking (grant no. 324257).
Original languageEnglish
Article numberP0529
Pages (from-to)S98
Number of pages1
JournalEpilepsia
Volume58
Issue numberS5
Publication statusPublished - Dec 2017
Event32nd International Epilepsy Congress - Barcelona, Spain
Duration: 2 Sep 20176 Sep 2017

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