Microreactors with integrated UV/Vis spectroscopic detection for online process analysis under segmented flow

J. Yue, F.H. Falke, J.C. Schouten, T.A. Nijhuis

Research output: Contribution to journalArticleAcademicpeer-review

43 Citations (Scopus)
119 Downloads (Pure)

Abstract

Combining reaction and detection in multiphase microfluidic flow is becoming increasingly important for accelerating process development in microreactors. We report the coupling of UV/Vis spectroscopy with microreactors for online process analysis under segmented flow conditions. Two integration schemes are presented: one uses a cross-type flow-through cell subsequent to a capillary microreactor for detection in the transmission mode; the other uses embedded waveguides on a microfluidic chip for detection in the evanescent wave field. Model experiments reveal the capabilities of the integrated systems in real-time concentration measurements and segmented flow characterization. The application of such integration for process analysis during gold nanoparticle synthesis is demonstrated, showing its great potential in process monitoring in microreactors operated under segmented flow.
Original languageEnglish
Pages (from-to)4855-4863
Number of pages8
JournalLab on a Chip
Volume13
DOIs
Publication statusPublished - 2013

Fingerprint

Dive into the research topics of 'Microreactors with integrated UV/Vis spectroscopic detection for online process analysis under segmented flow'. Together they form a unique fingerprint.

Cite this