TY - JOUR
T1 - Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays
AU - van der Maaden, K.
AU - Luttge, R.
AU - Vos, P.J.W.
AU - Bouwstra, J.
AU - Kersten, G.
AU - Ploemen, I.H.J.
PY - 2015/8
Y1 - 2015/8
N2 - In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based drug and vaccine delivery and could be a valuable addition to the other microneedle-based drug delivery approaches. To gain more insight into porous microneedle technologies, the scientific and patent literature is reviewed, and we focus on the possibilities and constraints of porous microneedle technologies for dermal drug delivery. Furthermore, we show preliminary data with commercially available porous microneedles and describe future directions in this field of research.
AB - In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based drug and vaccine delivery and could be a valuable addition to the other microneedle-based drug delivery approaches. To gain more insight into porous microneedle technologies, the scientific and patent literature is reviewed, and we focus on the possibilities and constraints of porous microneedle technologies for dermal drug delivery. Furthermore, we show preliminary data with commercially available porous microneedles and describe future directions in this field of research.
KW - (Trans)dermal drug delivery
KW - Microneedles
KW - Porous microneedles
U2 - 10.1007/s13346-015-0238-y
DO - 10.1007/s13346-015-0238-y
M3 - Article
C2 - 26044672
SN - 2190-393X
VL - 5
SP - 397
EP - 406
JO - Drug Delivery and Translational Research
JF - Drug Delivery and Translational Research
IS - 4
ER -
