A liquid cross-linker, epoxidized linseed oil (ELO), was encapsulated in a plastic with a high glass transition temperature (poly(N-vinyl-2-pyrrolidone); PVP). The process parameters of the spray-drying employed were optimized by a Design-of-Experiments (DoE) approach. Three factors concerning both the dispersion feed (total concentration of additive and core to encapsulant ratio) and the spray-drying processes (spray flow of the spray-drier) were chosen. A full 23 factorial Design of Experiments with center point was carried out in duplicate. The aim of the Design of Experiments was to understand and to optimize the encapsulation process in terms of total amount of epoxidized linseed oil in the powder (payload) and amount of epoxidized linseed oil enclosed in the olyvinylpyrrolidone (encapsulation efficiency). The results enabled the production of a free-flowing spray-dried powder of ELO encapsulated in PVP with an encapsulation efficiency of ~85%.