Mesoscale modulation of supramolecular ureidopyrimidinone-based poly(ethylene glycol) transient networks in water

R.E. Kieltyka, A.C.H. Pape, L. Albertazzi, Y. Nakano, M.M.C. Bastings, I.K. Voets, P.Y.W. Dankers, E.W. Meijer

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In natural systems, highly synergistic non-covalent interactions among biomolecular components exert mesoscopic control over hierarchical assemblies. We herein present a multicomponent self-assembly strategy to tune hierarchical supramolecular polymer architectures in water using highly affine and directional ureidopyrimidinone-poly-(ethylene glycol)s (UPy-PEG). Using scattering methods and oscillatory rheology, we observe the structural and mechanical regulation of entangled monofunctional UPy-PEG fibrils by cross-linking bifunctional UPy-PEG fibrils. This supramolecular mixing approach opens the door to a range of subtly distinct materials for chemical and biological applications.
Original languageEnglish
Pages (from-to)11159-11164
Number of pages6
JournalJournal of the American Chemical Society
Issue number30
Publication statusPublished - 2013

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