Abstract
We showed for the first time that MEMS actuation promotes in vitro Brain-on-Chip maturation for SH-SY5Y neuroblastoma cells and their networks. Utilizing a repetitive training program and subsequent calcium imaging (CI), we observed increased cellular electrophysiological activity with a trend for increased connectivity at a lower synaptic density, indicating a more matured network upon stimulation.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 957-958 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419017 |
| Publication status | Published - 2020 |
| Event | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online Duration: 4 Oct 2020 → 9 Oct 2020 |
Conference
| Conference | 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 |
|---|---|
| City | Virtual, Online |
| Period | 4/10/20 → 9/10/20 |
Keywords
- Brain-on-Chip
- Calcium imaging
- Mechanical stimulation
- Mechanotransduction
- SH-SY5Y