Mems actuation promotes in vitro brain-on-chip maturation

Alex Bastiaens, Gulden Akcay, Maaike Fransen, Sijia Xie, Regina Luttge

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

We showed for the first time that MEMS actuation promotes in vitro Brain-on-Chip maturation for SH-SY5Y neuroblastoma cells and their networks. Utilizing a repetitive training program and subsequent calcium imaging (CI), we observed increased cellular electrophysiological activity with a trend for increased connectivity at a lower synaptic density, indicating a more matured network upon stimulation.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages957-958
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 4 Oct 20209 Oct 2020

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period4/10/209/10/20

Keywords

  • Brain-on-Chip
  • Calcium imaging
  • Mechanical stimulation
  • Mechanotransduction
  • SH-SY5Y

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