Mechanoreciprocity in cell migration

S. van Helvert, C. Storm, P. Friedl

Research output: Contribution to journalArticleAcademicpeer-review

216 Citations (Scopus)


Cell migration is an adaptive process that depends on and responds to physical and molecular triggers. Moving cells sense and respond to tissue mechanics and induce transient or permanent tissue modifications, including extracellular matrix stiffening, compression and deformation, protein unfolding, proteolytic remodelling and jamming transitions. Here we discuss how the bi-directional relationship of cell-tissue interactions (mechanoreciprocity) allows cells to change position and contributes to single-cell and collective movement, structural and molecular tissue organization, and cell fate decisions.

Original languageEnglish
Pages (from-to)8-20
Number of pages13
JournalNature Cell Biology
Issue number1
Publication statusPublished - 1 Jan 2018


  • Animals
  • Biomechanical Phenomena
  • Bone and Bones/cytology
  • Brain/cytology
  • Cell Communication/physiology
  • Cell Differentiation
  • Cell Movement/physiology
  • Eukaryotic Cells/cytology
  • Extracellular Matrix/chemistry
  • Humans
  • Mechanotransduction, Cellular/physiology
  • Muscle, Skeletal/cytology
  • Organ Specificity
  • Proteolysis
  • Tendons/cytology


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