Mechanical properties of the porcine coronary artery

C.N. Broek, van den, M.C.M. Rutten, F.N. Vosse, van de

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Knowledge of mechanical properties of living arteries isimportant to understand vascular function during health, disease andintervention. A mechanical model of the vascular tree would facilitatethe development of (balloon-)catheters and stents.We have developed an ex vivo model in which a porcinecoronary artery can be kept at physiological circumstances; hencecoronary pressure and flow, cyclic longitudinal elongation of thesegment, physiological wall shear stresses, etc. are controlled, whileenabling measurement of its mechanical behavior. Arterial mechanicalbehavior was determined for segments of the porcine left anteriordescending coronary artery (LAD, fig. 1a) by simultaneousmeasurement of pressure (P), diameter (D) and axial force (Fax) duringdynamic loading at different axial strains. Also, the physiological axialstrain of the LAD was determined, based on the hypothesis that: Thein vivo axial strain of an artery is the strain at which the axial force isrelatively insensitive to changes in pressure [1,2], as shown in figure1b.
Original languageEnglish
Title of host publicationProceedings of the ASME 2008 Summer Bioengineering Conference (SBC2008), 25-29 June 2008, Marriott Resort, Marco Island, Florida, USA
EditorsB.B. Lieber, D.A. Vorp, R.E. Debski, O. Akkus
Place of PublicationUnited States, Marco Island
PublisherAmerican Society of Mechanical Engineers
ISBN (Print)0-7918-3825-0
DOIs
Publication statusPublished - 2008
EventASME 2008 Summer Bioengineering Conference (SBC2008) - Marco Island, United States
Duration: 25 Jun 200829 Jun 2008
Conference number: 10

Conference

ConferenceASME 2008 Summer Bioengineering Conference (SBC2008)
Abbreviated titleSBC 2008
CountryUnited States
CityMarco Island
Period25/06/0829/06/08

Fingerprint

Coronary Vessels
Swine
Arteries
Pressure
Blood Vessels
Telefacsimile
Stents
Catheters
Health

Cite this

Broek, van den, C. N., Rutten, M. C. M., & Vosse, van de, F. N. (2008). Mechanical properties of the porcine coronary artery. In B. B. Lieber, D. A. Vorp, R. E. Debski, & O. Akkus (Eds.), Proceedings of the ASME 2008 Summer Bioengineering Conference (SBC2008), 25-29 June 2008, Marriott Resort, Marco Island, Florida, USA United States, Marco Island: American Society of Mechanical Engineers. https://doi.org/10.1115/SBC2008-192777
Broek, van den, C.N. ; Rutten, M.C.M. ; Vosse, van de, F.N. / Mechanical properties of the porcine coronary artery. Proceedings of the ASME 2008 Summer Bioengineering Conference (SBC2008), 25-29 June 2008, Marriott Resort, Marco Island, Florida, USA. editor / B.B. Lieber ; D.A. Vorp ; R.E. Debski ; O. Akkus. United States, Marco Island : American Society of Mechanical Engineers, 2008.
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abstract = "Knowledge of mechanical properties of living arteries isimportant to understand vascular function during health, disease andintervention. A mechanical model of the vascular tree would facilitatethe development of (balloon-)catheters and stents.We have developed an ex vivo model in which a porcinecoronary artery can be kept at physiological circumstances; hencecoronary pressure and flow, cyclic longitudinal elongation of thesegment, physiological wall shear stresses, etc. are controlled, whileenabling measurement of its mechanical behavior. Arterial mechanicalbehavior was determined for segments of the porcine left anteriordescending coronary artery (LAD, fig. 1a) by simultaneousmeasurement of pressure (P), diameter (D) and axial force (Fax) duringdynamic loading at different axial strains. Also, the physiological axialstrain of the LAD was determined, based on the hypothesis that: Thein vivo axial strain of an artery is the strain at which the axial force isrelatively insensitive to changes in pressure [1,2], as shown in figure1b.",
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Broek, van den, CN, Rutten, MCM & Vosse, van de, FN 2008, Mechanical properties of the porcine coronary artery. in BB Lieber, DA Vorp, RE Debski & O Akkus (eds), Proceedings of the ASME 2008 Summer Bioengineering Conference (SBC2008), 25-29 June 2008, Marriott Resort, Marco Island, Florida, USA. American Society of Mechanical Engineers, United States, Marco Island, ASME 2008 Summer Bioengineering Conference (SBC2008), Marco Island, United States, 25/06/08. https://doi.org/10.1115/SBC2008-192777

Mechanical properties of the porcine coronary artery. / Broek, van den, C.N.; Rutten, M.C.M.; Vosse, van de, F.N.

Proceedings of the ASME 2008 Summer Bioengineering Conference (SBC2008), 25-29 June 2008, Marriott Resort, Marco Island, Florida, USA. ed. / B.B. Lieber; D.A. Vorp; R.E. Debski; O. Akkus. United States, Marco Island : American Society of Mechanical Engineers, 2008.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

TY - GEN

T1 - Mechanical properties of the porcine coronary artery

AU - Broek, van den, C.N.

AU - Rutten, M.C.M.

AU - Vosse, van de, F.N.

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N2 - Knowledge of mechanical properties of living arteries isimportant to understand vascular function during health, disease andintervention. A mechanical model of the vascular tree would facilitatethe development of (balloon-)catheters and stents.We have developed an ex vivo model in which a porcinecoronary artery can be kept at physiological circumstances; hencecoronary pressure and flow, cyclic longitudinal elongation of thesegment, physiological wall shear stresses, etc. are controlled, whileenabling measurement of its mechanical behavior. Arterial mechanicalbehavior was determined for segments of the porcine left anteriordescending coronary artery (LAD, fig. 1a) by simultaneousmeasurement of pressure (P), diameter (D) and axial force (Fax) duringdynamic loading at different axial strains. Also, the physiological axialstrain of the LAD was determined, based on the hypothesis that: Thein vivo axial strain of an artery is the strain at which the axial force isrelatively insensitive to changes in pressure [1,2], as shown in figure1b.

AB - Knowledge of mechanical properties of living arteries isimportant to understand vascular function during health, disease andintervention. A mechanical model of the vascular tree would facilitatethe development of (balloon-)catheters and stents.We have developed an ex vivo model in which a porcinecoronary artery can be kept at physiological circumstances; hencecoronary pressure and flow, cyclic longitudinal elongation of thesegment, physiological wall shear stresses, etc. are controlled, whileenabling measurement of its mechanical behavior. Arterial mechanicalbehavior was determined for segments of the porcine left anteriordescending coronary artery (LAD, fig. 1a) by simultaneousmeasurement of pressure (P), diameter (D) and axial force (Fax) duringdynamic loading at different axial strains. Also, the physiological axialstrain of the LAD was determined, based on the hypothesis that: Thein vivo axial strain of an artery is the strain at which the axial force isrelatively insensitive to changes in pressure [1,2], as shown in figure1b.

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M3 - Conference contribution

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BT - Proceedings of the ASME 2008 Summer Bioengineering Conference (SBC2008), 25-29 June 2008, Marriott Resort, Marco Island, Florida, USA

A2 - Lieber, B.B.

A2 - Vorp, D.A.

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A2 - Akkus, O.

PB - American Society of Mechanical Engineers

CY - United States, Marco Island

ER -

Broek, van den CN, Rutten MCM, Vosse, van de FN. Mechanical properties of the porcine coronary artery. In Lieber BB, Vorp DA, Debski RE, Akkus O, editors, Proceedings of the ASME 2008 Summer Bioengineering Conference (SBC2008), 25-29 June 2008, Marriott Resort, Marco Island, Florida, USA. United States, Marco Island: American Society of Mechanical Engineers. 2008 https://doi.org/10.1115/SBC2008-192777