TY - JOUR
T1 - Mechanical blood-tissue interaction in contracting muscles : a model study
AU - Vankan, W.J.
AU - Huyghe, J.M.R.J.
AU - Donkelaar, van, C.C.
AU - Drost, M.R.
AU - Janssen, J.D.
AU - Huson, A.
PY - 1998
Y1 - 1998
N2 - A finite element (FE) model of blood perfused biological tissue has been developed. Blood perfusion is described by fluid flow through a series of 5 intercommunicating vascular compartments that are embedded in the tissue. Each compartment is characterized by a blood flow permeability tensor, blood volume fraction and vessel compliance. Local non-linear relationships between intra-extravascular pressure difference and blood volume fraction, and between blood volume fraction and the permeability tensor, are includedin the FE model. To test the implementation of these non-linear relations, FE results of blood perfusion in a piece of tissue that is subject to increased intramuscular pressure, are compared to results that are calculated with a lumped parameter (LP) model of blood perfusion. FE simulation of blood flow through a contracting rat calf muscle is performed. The FE model used in this simulation contains a transversely isotropic, non-linearly elastic description of deforming muscle tissue, in which local contraction stress is prescribed as a function of time. FE results of muscle tension, total arterial inflow and total venous outflow of the muscle during contraction, correspond to experimental results of an isometrically and tetanically contracting rat calf muscle.
AB - A finite element (FE) model of blood perfused biological tissue has been developed. Blood perfusion is described by fluid flow through a series of 5 intercommunicating vascular compartments that are embedded in the tissue. Each compartment is characterized by a blood flow permeability tensor, blood volume fraction and vessel compliance. Local non-linear relationships between intra-extravascular pressure difference and blood volume fraction, and between blood volume fraction and the permeability tensor, are includedin the FE model. To test the implementation of these non-linear relations, FE results of blood perfusion in a piece of tissue that is subject to increased intramuscular pressure, are compared to results that are calculated with a lumped parameter (LP) model of blood perfusion. FE simulation of blood flow through a contracting rat calf muscle is performed. The FE model used in this simulation contains a transversely isotropic, non-linearly elastic description of deforming muscle tissue, in which local contraction stress is prescribed as a function of time. FE results of muscle tension, total arterial inflow and total venous outflow of the muscle during contraction, correspond to experimental results of an isometrically and tetanically contracting rat calf muscle.
U2 - 10.1016/S0021-9290(98)00014-1
DO - 10.1016/S0021-9290(98)00014-1
M3 - Article
VL - 31
SP - 401
EP - 409
JO - Journal of Biomechanics
JF - Journal of Biomechanics
SN - 0021-9290
IS - 5
ER -