Maximum-likelihood estimation for indicator dilution analysis

M.P.J. Kuenen, I.H.F. Herold, H.H.M. Korsten, J.J.M.C.H. Rosette, de la, H. Wijkstra, M. Mischi

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)


Indicator-dilution methods are widely used by many medical imaging techniques and by dye-, lithium-, and thermodilution measurements. The measured indicator dilution curves are typically fitted by a mathematical model to estimate the hemodynamic parameters of interest. This paper presents a new maximum-likelihood algorithm for parameter estimation, where indicator dilution curves are considered as the histogram of underlying transit-time distribution. Apart from a general description of the algorithm, semi-analytical solutions are provided for three well-known indicator dilution models. An adaptation of the algorithm is also introduced to cope with indicator recirculation. In simulations as well as in experimental data obtained by dynamic contrast-enhanced ultrasound imaging, the proposed algorithm shows a superior parameter estimation accuracy over nonlinear least-squares regression. The feasibility of the algorithm for use in vivo is evaluated using dynamic contrastenhanced ultrasound recordings obtained with the purpose of prostate cancer detection. The proposed algorithm shows an improved ability (increase in receiver-operating-characteristic curve area of up to 0.13) with respect to existing methods to differentiate between healthy tissue and cancer.
Original languageEnglish
Pages (from-to)821-831
Number of pages11
JournalIEEE Transactions on Biomedical Engineering
Issue number3
Publication statusPublished - 2014


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