Masterclass : magnetic particles in motion for biosensing

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademic

Abstract

The aging population and increases in chronic diseases put high pressure on the healthcare system and drive a need for easy to use and cost-effective medical technologies. In-vitro diagnostics (IVD) plays a large role in delivering healthcare and within the IVD market, decentralized diagnostic testing, i.e. point-of-care testing (POCT), is a growing segment. POCT devices should be compact and fully integrated for maximum ease of use. A new class of POCT devices is appearing based on the use of actuated magnetic particles. The use of magnetic particles has important advantages: they have a large surface-to-volume ratio, are conveniently bio-functionalized, provide a large optical contrast, and they can be manipulated by magnetic fields for full control of the integrated biosensing assay. In this lecture, I will review the use of magnetic particles actuated by magnetic fields to realize integrated lab-on-chip diagnostic devices wherein several assay process steps are combined, e.g. to mix fluids, capture analytes, concentrate analytes, transfer analytes, label analytes, and perform stringency and washing steps. I will focus on realizations within the concept of stationary microfluidics, in which fluid manipulation is minimized and the assay steps are essentially effectuated by magnetic particles and magnetic forces. I will discuss efforts to combine and integrate different magnetically actuated assay steps, with the vision that it will become possible in the future to realize integrated, cost-effective and easy to use stationary-fluidic biosensing systems in which all assay process steps are controlled and optimized by magnetic forces.
Original languageEnglish
Title of host publicationProceedings of the 1st International Conference on Micro and Nanofluidics, FLOW 2014, 18-21 May 2014, Enschede, The Netherlands
Publication statusPublished - 2014
Event1st International Conference on Micro & Nanofluidics (FLOW 2014), May 18-21, 2014, Enschede, The Netherlands - University of Twente, Enschede, Netherlands
Duration: 18 May 201421 May 2014
http://www.flow14conference.com/

Conference

Conference1st International Conference on Micro & Nanofluidics (FLOW 2014), May 18-21, 2014, Enschede, The Netherlands
Abbreviated titleFLOW 2014
Country/TerritoryNetherlands
CityEnschede
Period18/05/1421/05/14
Other"Fundamentals and Applications"
Internet address

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