Abstract
The aging population and increases in chronic diseases put high pressure on the healthcare system and drive a need for easy to use and cost-effective medical technologies. In-vitro diagnostics (IVD) plays a large role in delivering healthcare and within the IVD market, decentralized diagnostic testing, i.e. point-of-care testing (POCT), is a growing segment. POCT devices should be compact and fully integrated for maximum ease of use. A new class of POCT devices is appearing based on the use of actuated magnetic particles. The use of magnetic particles has important advantages: they have a large surface-to-volume ratio, are conveniently bio-functionalized, provide a large optical contrast, and they can be manipulated by magnetic fields for full control of the integrated biosensing assay.
In this lecture, I will review the use of magnetic particles actuated by magnetic fields to realize integrated lab-on-chip diagnostic devices wherein several assay process steps are combined, e.g. to mix fluids, capture analytes, concentrate analytes, transfer analytes, label analytes, and perform stringency and washing steps. I will focus on realizations within the concept of stationary microfluidics, in which fluid manipulation is minimized and the assay steps are essentially effectuated by magnetic particles and magnetic forces. I will discuss efforts to combine and integrate different magnetically actuated assay steps, with the vision that it will become possible in the future to realize integrated, cost-effective and easy to use stationary-fluidic biosensing systems in which all assay process steps are controlled and optimized by magnetic forces.
Original language | English |
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Title of host publication | Proceedings of the 1st International Conference on Micro and Nanofluidics, FLOW 2014, 18-21 May 2014, Enschede, The Netherlands |
Publication status | Published - 2014 |
Event | 1st International Conference on Micro & Nanofluidics (FLOW 2014), May 18-21, 2014, Enschede, The Netherlands - University of Twente, Enschede, Netherlands Duration: 18 May 2014 → 21 May 2014 http://www.flow14conference.com/ |
Conference
Conference | 1st International Conference on Micro & Nanofluidics (FLOW 2014), May 18-21, 2014, Enschede, The Netherlands |
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Abbreviated title | FLOW 2014 |
Country/Territory | Netherlands |
City | Enschede |
Period | 18/05/14 → 21/05/14 |
Other | "Fundamentals and Applications" |
Internet address |