Studies of knowledge and innovation as driving forces of regional development and growth offer a myriad of approaches. Here, questions asked, methods used and answers given are manifold. In our overview, we cover recent developments in this research area. Moreover, we explore the question as to the extent to which approaches in this research area compete with or complement one another. It turns out that the various studies are much more complementary than competitive. However, there is still much ground to be covered before we fully understand the processes underlying the creation and dissemination of knowledge and innovation leading to regional development and growth.