Male subfertility and oxidative stress

Emily P.P. Evans; Jorien T.M. Scholten; Aldona Mzyk; Claudia Reyes-San-Martin; Arturo E. Llumbet; Thamir Hamoh; Eus G.J.M. Arts; Romana Schirhagl; Astrid E.P. Cantineau

doi:10.1016/j.redox.2021.102071

Male subfertility and oxidative stress

Emily P.P. Evans, Jorien T.M. Scholten, Aldona Mzyk, Claudia Reyes-San-Martin, Arturo E. Llumbet, Thamir Hamoh, Eus G.J.M. Arts, Romana Schirhagl (Corresponding author), Astrid E.P. Cantineau (Corresponding author)

Research output: Contribution to journal › Review article › peer-review

88 Citations (Scopus)

Abstract

To date 15% of couples are suffering from infertility with 45–50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to increase. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

Original language	English
Article number	102071
Number of pages	17
Journal	Redox Biology
Volume	46
DOIs	https://doi.org/10.1016/j.redox.2021.102071
Publication status	Published - Oct 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 The Authors

Keywords

Infertility
Oxidative stress
Reactive oxygen species
Sperm
Subfertility

Access to Document

10.1016/j.redox.2021.102071

Cite this

@article{ef0a32cd70af41fbb91876592167c27f,

title = "Male subfertility and oxidative stress",

abstract = "To date 15% of couples are suffering from infertility with 45–50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to increase. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.",

keywords = "Infertility, Oxidative stress, Reactive oxygen species, Sperm, Subfertility",

author = "Evans, {Emily P.P.} and Scholten, {Jorien T.M.} and Aldona Mzyk and Claudia Reyes-San-Martin and Llumbet, {Arturo E.} and Thamir Hamoh and Arts, {Eus G.J.M.} and Romana Schirhagl and Cantineau, {Astrid E.P.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = oct,

doi = "10.1016/j.redox.2021.102071",

language = "English",

volume = "46",

journal = "Redox Biology",

issn = "2213-2317",

publisher = "Elsevier",

}

TY - JOUR

T1 - Male subfertility and oxidative stress

AU - Evans, Emily P.P.

AU - Scholten, Jorien T.M.

AU - Mzyk, Aldona

AU - Reyes-San-Martin, Claudia

AU - Llumbet, Arturo E.

AU - Hamoh, Thamir

AU - Arts, Eus G.J.M.

AU - Schirhagl, Romana

AU - Cantineau, Astrid E.P.

PY - 2021/10

Y1 - 2021/10

N2 - To date 15% of couples are suffering from infertility with 45–50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to increase. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

AB - To date 15% of couples are suffering from infertility with 45–50% of males being responsible. With an increase in paternal age as well as various environmental and lifestyle factors worsening these figures are expected to increase. As the so-called free radical theory of infertility suggests, free radicals or reactive oxygen species (ROS) play an essential role in this process. However, ROS also fulfill important functions for instance in sperm maturation. The aim of this review article is to discuss the role reactive oxygen species play in male fertility and how these are influenced by lifestyle, age or disease. We will further discuss how these ROS are measured and how they can be avoided during in-vitro fertilization.

KW - Infertility

KW - Oxidative stress

KW - Reactive oxygen species

KW - Sperm

KW - Subfertility

UR - http://www.scopus.com/inward/record.url?scp=85111576395&partnerID=8YFLogxK

U2 - 10.1016/j.redox.2021.102071

DO - 10.1016/j.redox.2021.102071

M3 - Review article

C2 - 34340027

AN - SCOPUS:85111576395

SN - 2213-2317

VL - 46

JO - Redox Biology

JF - Redox Biology

M1 - 102071

ER -

Male subfertility and oxidative stress

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this