Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics

Maria V. Efremova; Victor A. Naumenko; Marina Spasova; Anastasiia S. Garanina; Maxim A. Abakumov; Anastasia D. Blokhina; Pavel A. Melnikov; Alexandra O. Prelovskaya; Markus Heidelmann; Zi-An Li; Zheng Ma; Igor V. Shchetinin; Yuri I. Golovin; Igor I. Kireev; Alexander G. Savchenko; Vladimir P. Chekhonin; Natalia L. Klyachko; Michael Farle; Alexander G. Majouga; Ulf Wiedwald

doi:10.1038/s41598-018-29618-w

Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics

Maria V. Efremova
, Victor A. Naumenko
, Marina Spasova
, Anastasiia S. Garanina
, Maxim A. Abakumov
, Anastasia D. Blokhina
, Pavel A. Melnikov
, Alexandra O. Prelovskaya
, Markus Heidelmann
, Zi-An Li
, Zheng Ma
, Igor V. Shchetinin
, Yuri I. Golovin
, Igor I. Kireev
, Alexander G. Savchenko
, Vladimir P. Chekhonin
, Natalia L. Klyachko
, Michael Farle
, Alexander G. Majouga
, Ulf Wiedwald

Research output: Contribution to journal › Article › Academic › peer-review

97 Citations (Scopus)

Abstract

High-quality, 25 nm octahedral-shaped Fe ₃ O ₄ magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe ₃ O ₄ -Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T ₂ relaxivity for magnetic resonance imaging as compared to other types of Fe ₃ O ₄ -Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe ₃ O ₄ -Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo. The delivery to tumors and payload release are demonstrated in real time by intravital microscopy. Replacing the dyes by cell-specific molecules and drugs makes the Fe ₃ O ₄ -Au hybrids a unique all-in-one platform for theranostics.

Original language	English
Article number	11295
Number of pages	19
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-29618-w
Publication status	Published - Dec 2018
Externally published	Yes

Funding

We thank Astrid M. Westendorf for fruitful discussions. The authors gratefully acknowledge the financial support of the Ministry of Education and Science of the Russian Federation in the framework of Increase Competitiveness Program of NUST «MISiS» No. K2-2016-069 (synthesis of nanomaterials). U.W. gratefully acknowledges the financial support of the Ministry of Education and Science of the Russian Federation in the framework of Increase Competitiveness Program of NUST «MISiS» № K3-2017-022 (magnetic measurements). V.A.N. gratefully acknowledges the financial support of the Ministry of Education and Science of the Russian Federation in the framework of Increase Competitiveness Program of NUST «MISiS» (№ K4-2017-046), implemented by a governmental decree dated 16th of March 2013, N 211 (intravital microscopy). The reported study was funded by Russian Foundation for Basic Research (RFBR) according to the research project № 18-33-01232 (fluorescent labeling of nanoparticles). The authors also acknowledge financial support of Russian Science Foundation № 17-14-01316 (biological study) and Lomonosov Moscow State University Development Program PNR 5.13 (electron microscopy). MRI measurements were carried out by ClinScan 7 T (Bruker Biospin) located at CKP «Medical Nanobiotechnology». We acknowledge support by the Open Access Publication Fund of the University of Duisburg-Essen.

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10.1038/s41598-018-29618-w

Cite this

Efremova, M. V., Naumenko, V. A., Spasova, M., Garanina, A. S., Abakumov, M. A., Blokhina, A. D., Melnikov, P. A., Prelovskaya, A. O., Heidelmann, M., Li, Z.-A., Ma, Z., Shchetinin, I. V., Golovin, Y. I., Kireev, I. I., Savchenko, A. G., Chekhonin, V. P., Klyachko, N. L., Farle, M., Majouga, A. G., & Wiedwald, U. (2018). Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics. Scientific Reports, 8(1), Article 11295. https://doi.org/10.1038/s41598-018-29618-w

@article{95296f2113fb4811afca385d1e1b1961,

title = "Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics",

abstract = " High-quality, 25 nm octahedral-shaped Fe 3 O 4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe 3 O 4 -Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T 2 relaxivity for magnetic resonance imaging as compared to other types of Fe 3 O 4 -Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe 3 O 4 -Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo. The delivery to tumors and payload release are demonstrated in real time by intravital microscopy. Replacing the dyes by cell-specific molecules and drugs makes the Fe 3 O 4 -Au hybrids a unique all-in-one platform for theranostics. ",

author = "Efremova, \{Maria V.\} and Naumenko, \{Victor A.\} and Marina Spasova and Garanina, \{Anastasiia S.\} and Abakumov, \{Maxim A.\} and Blokhina, \{Anastasia D.\} and Melnikov, \{Pavel A.\} and Prelovskaya, \{Alexandra O.\} and Markus Heidelmann and Zi-An Li and Zheng Ma and Shchetinin, \{Igor V.\} and Golovin, \{Yuri I.\} and Kireev, \{Igor I.\} and Savchenko, \{Alexander G.\} and Chekhonin, \{Vladimir P.\} and Klyachko, \{Natalia L.\} and Michael Farle and Majouga, \{Alexander G.\} and Ulf Wiedwald",

note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",

year = "2018",

month = dec,

doi = "10.1038/s41598-018-29618-w",

language = "English",

volume = "8",

journal = "Scientific Reports",

issn = "2045-2322",

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Efremova, MV, Naumenko, VA, Spasova, M, Garanina, AS, Abakumov, MA, Blokhina, AD, Melnikov, PA, Prelovskaya, AO, Heidelmann, M, Li, Z-A, Ma, Z, Shchetinin, IV, Golovin, YI, Kireev, II, Savchenko, AG, Chekhonin, VP, Klyachko, NL, Farle, M, Majouga, AG & Wiedwald, U 2018, 'Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics', Scientific Reports, vol. 8, no. 1, 11295. https://doi.org/10.1038/s41598-018-29618-w

TY - JOUR

T1 - Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics

AU - Efremova, Maria V.

AU - Naumenko, Victor A.

AU - Spasova, Marina

AU - Garanina, Anastasiia S.

AU - Abakumov, Maxim A.

AU - Blokhina, Anastasia D.

AU - Melnikov, Pavel A.

AU - Prelovskaya, Alexandra O.

AU - Heidelmann, Markus

AU - Li, Zi-An

AU - Ma, Zheng

AU - Shchetinin, Igor V.

AU - Golovin, Yuri I.

AU - Kireev, Igor I.

AU - Savchenko, Alexander G.

AU - Chekhonin, Vladimir P.

AU - Klyachko, Natalia L.

AU - Farle, Michael

AU - Majouga, Alexander G.

AU - Wiedwald, Ulf

PY - 2018/12

Y1 - 2018/12

N2 - High-quality, 25 nm octahedral-shaped Fe 3 O 4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe 3 O 4 -Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T 2 relaxivity for magnetic resonance imaging as compared to other types of Fe 3 O 4 -Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe 3 O 4 -Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo. The delivery to tumors and payload release are demonstrated in real time by intravital microscopy. Replacing the dyes by cell-specific molecules and drugs makes the Fe 3 O 4 -Au hybrids a unique all-in-one platform for theranostics.

AB - High-quality, 25 nm octahedral-shaped Fe 3 O 4 magnetite nanocrystals are epitaxially grown on 9 nm Au seed nanoparticles using a modified wet-chemical synthesis. These Fe 3 O 4 -Au Janus nanoparticles exhibit bulk-like magnetic properties. Due to their high magnetization and octahedral shape, the hybrids show superior in vitro and in vivo T 2 relaxivity for magnetic resonance imaging as compared to other types of Fe 3 O 4 -Au hybrids and commercial contrast agents. The nanoparticles provide two functional surfaces for theranostic applications. For the first time, Fe 3 O 4 -Au hybrids are conjugated with two fluorescent dyes or the combination of drug and dye allowing the simultaneous tracking of the nanoparticle vehicle and the drug cargo in vitro and in vivo. The delivery to tumors and payload release are demonstrated in real time by intravital microscopy. Replacing the dyes by cell-specific molecules and drugs makes the Fe 3 O 4 -Au hybrids a unique all-in-one platform for theranostics.

UR - https://www.scopus.com/pages/publications/85050696761

U2 - 10.1038/s41598-018-29618-w

DO - 10.1038/s41598-018-29618-w

M3 - Article

C2 - 30050080

AN - SCOPUS:85050696761

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 11295

ER -

Magnetite-Gold nanohybrids as ideal all-in-one platforms for theranostics

Abstract

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