Logic modeling in quantitative systems pharmacology

P. Traynard, L. Tobalina, F. Eduati, L. Calzone, J. Saez-Rodriguez (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
36 Downloads (Pure)

Abstract

Here we present logic modeling as an approach to understand deregulation of signal transduction in disease and to characterize a drug's mode of action. We discuss how to build a logic model from the literature and experimental data and how to analyze the resulting model to obtain insights of relevance for systems pharmacology. Our workflow uses the free tools OmniPath (network reconstruction from the literature), CellNOpt (model fit to experimental data), MaBoSS (model analysis), and Cytoscape (visualization).

Original languageEnglish
Pages (from-to)499-511
Number of pages13
JournalCPT: Pharmacometrics & Systems Pharmacology
Volume6
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017
Externally publishedYes

    Fingerprint

Keywords

  • Journal Article

Cite this