Local mechanical properties of atherosclerotic plaque tissue

C.-K. Chai, A.C. Akyildiz, L. Speelman, F.J.H. Gijsen, C.W.J. Oomens, M.R.H.M. Sambeek, van, A. Lugt, van der, F.P.T. Baaijens

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Abstract

The fibrous cap of an atherosclerotic plaque may be prone to rupture if the occurring stresses exceed the strength of the cap. Rupture can cause acute thrombosis and subsequent ischemic stroke or myocardial infarction. A reliable prediction of the rupture probability is essential for the diagnosis and treatment of atherosclerosis. Biomechanical models, which compute stresses and strain, are promising to provide a more reliable rupture risk prediction. However, these models require knowledge of the local biomechanical properties of atherosclerotic plaque tissue. For this purpose, we examined human carotid plaques using indentation experiments. The test set-up was mounted on an inverted confocal microscope to visualise the collagen fibre structure during the tests. By using an inverse finite element (FE) approach, and assuming isotropic neo-Hookean behaviour, the corresponding Young’s moduli were found in the range from 6 to 891 kPa (median 30 kPa). The results correspond to the values obtained by other research groups who analysed the compressive Young’s modulus of atherosclerotic plaques. Collagen rich locations showed to be stiffer than collagen poor locations. No significant differences were found between the Young’s moduli of structured and unstructured collagen architectures as specified from confocal collagen data. Insignificant differences between the middle of the fibrous cap, the shoulder regions, and remaining plaque tissue locations indicate that axial, compressive mechanical properties of atherosclerotic plaques are independent of location within the plaque.
Original languageEnglish
Publication statusPublished - 2012
EventMate Poster Award 2012 : 17th Annual Poster Contest -
Duration: 1 Jan 201217 Dec 2012

Conference

ConferenceMate Poster Award 2012 : 17th Annual Poster Contest
Period1/01/1217/12/12
OtherMate Poster Award 2012 : 17th Annual Poster Contest

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Atherosclerotic Plaques
Collagen
Rupture
Elastic Modulus
Atherosclerosis
Thrombosis
Stroke
Myocardial Infarction
Research

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Chai, C-K., Akyildiz, A. C., Speelman, L., Gijsen, F. J. H., Oomens, C. W. J., Sambeek, van, M. R. H. M., ... Baaijens, F. P. T. (2012). Local mechanical properties of atherosclerotic plaque tissue. Poster session presented at Mate Poster Award 2012 : 17th Annual Poster Contest, .
Chai, C.-K. ; Akyildiz, A.C. ; Speelman, L. ; Gijsen, F.J.H. ; Oomens, C.W.J. ; Sambeek, van, M.R.H.M. ; Lugt, van der, A. ; Baaijens, F.P.T. / Local mechanical properties of atherosclerotic plaque tissue. Poster session presented at Mate Poster Award 2012 : 17th Annual Poster Contest, .
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title = "Local mechanical properties of atherosclerotic plaque tissue",
abstract = "The fibrous cap of an atherosclerotic plaque may be prone to rupture if the occurring stresses exceed the strength of the cap. Rupture can cause acute thrombosis and subsequent ischemic stroke or myocardial infarction. A reliable prediction of the rupture probability is essential for the diagnosis and treatment of atherosclerosis. Biomechanical models, which compute stresses and strain, are promising to provide a more reliable rupture risk prediction. However, these models require knowledge of the local biomechanical properties of atherosclerotic plaque tissue. For this purpose, we examined human carotid plaques using indentation experiments. The test set-up was mounted on an inverted confocal microscope to visualise the collagen fibre structure during the tests. By using an inverse finite element (FE) approach, and assuming isotropic neo-Hookean behaviour, the corresponding Young’s moduli were found in the range from 6 to 891 kPa (median 30 kPa). The results correspond to the values obtained by other research groups who analysed the compressive Young’s modulus of atherosclerotic plaques. Collagen rich locations showed to be stiffer than collagen poor locations. No significant differences were found between the Young’s moduli of structured and unstructured collagen architectures as specified from confocal collagen data. Insignificant differences between the middle of the fibrous cap, the shoulder regions, and remaining plaque tissue locations indicate that axial, compressive mechanical properties of atherosclerotic plaques are independent of location within the plaque.",
author = "C.-K. Chai and A.C. Akyildiz and L. Speelman and F.J.H. Gijsen and C.W.J. Oomens and {Sambeek, van}, M.R.H.M. and {Lugt, van der}, A. and F.P.T. Baaijens",
year = "2012",
language = "English",
note = "Mate Poster Award 2012 : 17th Annual Poster Contest ; Conference date: 01-01-2012 Through 17-12-2012",

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Chai, C-K, Akyildiz, AC, Speelman, L, Gijsen, FJH, Oomens, CWJ, Sambeek, van, MRHM, Lugt, van der, A & Baaijens, FPT 2012, 'Local mechanical properties of atherosclerotic plaque tissue' Mate Poster Award 2012 : 17th Annual Poster Contest, 1/01/12 - 17/12/12, .

Local mechanical properties of atherosclerotic plaque tissue. / Chai, C.-K.; Akyildiz, A.C.; Speelman, L.; Gijsen, F.J.H.; Oomens, C.W.J.; Sambeek, van, M.R.H.M.; Lugt, van der, A.; Baaijens, F.P.T.

2012. Poster session presented at Mate Poster Award 2012 : 17th Annual Poster Contest, .

Research output: Contribution to conferencePosterAcademic

TY - CONF

T1 - Local mechanical properties of atherosclerotic plaque tissue

AU - Chai, C.-K.

AU - Akyildiz, A.C.

AU - Speelman, L.

AU - Gijsen, F.J.H.

AU - Oomens, C.W.J.

AU - Sambeek, van, M.R.H.M.

AU - Lugt, van der, A.

AU - Baaijens, F.P.T.

PY - 2012

Y1 - 2012

N2 - The fibrous cap of an atherosclerotic plaque may be prone to rupture if the occurring stresses exceed the strength of the cap. Rupture can cause acute thrombosis and subsequent ischemic stroke or myocardial infarction. A reliable prediction of the rupture probability is essential for the diagnosis and treatment of atherosclerosis. Biomechanical models, which compute stresses and strain, are promising to provide a more reliable rupture risk prediction. However, these models require knowledge of the local biomechanical properties of atherosclerotic plaque tissue. For this purpose, we examined human carotid plaques using indentation experiments. The test set-up was mounted on an inverted confocal microscope to visualise the collagen fibre structure during the tests. By using an inverse finite element (FE) approach, and assuming isotropic neo-Hookean behaviour, the corresponding Young’s moduli were found in the range from 6 to 891 kPa (median 30 kPa). The results correspond to the values obtained by other research groups who analysed the compressive Young’s modulus of atherosclerotic plaques. Collagen rich locations showed to be stiffer than collagen poor locations. No significant differences were found between the Young’s moduli of structured and unstructured collagen architectures as specified from confocal collagen data. Insignificant differences between the middle of the fibrous cap, the shoulder regions, and remaining plaque tissue locations indicate that axial, compressive mechanical properties of atherosclerotic plaques are independent of location within the plaque.

AB - The fibrous cap of an atherosclerotic plaque may be prone to rupture if the occurring stresses exceed the strength of the cap. Rupture can cause acute thrombosis and subsequent ischemic stroke or myocardial infarction. A reliable prediction of the rupture probability is essential for the diagnosis and treatment of atherosclerosis. Biomechanical models, which compute stresses and strain, are promising to provide a more reliable rupture risk prediction. However, these models require knowledge of the local biomechanical properties of atherosclerotic plaque tissue. For this purpose, we examined human carotid plaques using indentation experiments. The test set-up was mounted on an inverted confocal microscope to visualise the collagen fibre structure during the tests. By using an inverse finite element (FE) approach, and assuming isotropic neo-Hookean behaviour, the corresponding Young’s moduli were found in the range from 6 to 891 kPa (median 30 kPa). The results correspond to the values obtained by other research groups who analysed the compressive Young’s modulus of atherosclerotic plaques. Collagen rich locations showed to be stiffer than collagen poor locations. No significant differences were found between the Young’s moduli of structured and unstructured collagen architectures as specified from confocal collagen data. Insignificant differences between the middle of the fibrous cap, the shoulder regions, and remaining plaque tissue locations indicate that axial, compressive mechanical properties of atherosclerotic plaques are independent of location within the plaque.

M3 - Poster

ER -

Chai C-K, Akyildiz AC, Speelman L, Gijsen FJH, Oomens CWJ, Sambeek, van MRHM et al. Local mechanical properties of atherosclerotic plaque tissue. 2012. Poster session presented at Mate Poster Award 2012 : 17th Annual Poster Contest, .