Local mechanical properties of atherosclerotic plaque tissue

C.-K. Chai, A.C. Akyildiz, L. Speelman, F.J.H. Gijsen, C.W.J. Oomens, M.R.H.M. Sambeek, van, A. Lugt, van der, F.P.T. Baaijens

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Abstract

The fibrous cap of an atherosclerotic plaque may be prone to rupture if the occurring stresses exceed the strength of the cap. Rupture can cause acute thrombosis and subsequent ischemic stroke or myocardial infarction. A reliable prediction of the rupture probability is essential for the diagnosis and treatment of atherosclerosis. Biomechanical models, which compute stresses and strain, are promising to provide a more reliable rupture risk prediction. However, these models require knowledge of the local biomechanical properties of atherosclerotic plaque tissue. For this purpose, we examined human carotid plaques using indentation experiments. The test set-up was mounted on an inverted confocal microscope to visualise the collagen fibre structure during the tests. By using an inverse finite element (FE) approach, and assuming isotropic neo-Hookean behaviour, the corresponding Young’s moduli were found in the range from 6 to 891 kPa (median 30 kPa). The results correspond to the values obtained by other research groups who analysed the compressive Young’s modulus of atherosclerotic plaques. Collagen rich locations showed to be stiffer than collagen poor locations. No significant differences were found between the Young’s moduli of structured and unstructured collagen architectures as specified from confocal collagen data. Insignificant differences between the middle of the fibrous cap, the shoulder regions, and remaining plaque tissue locations indicate that axial, compressive mechanical properties of atherosclerotic plaques are independent of location within the plaque.
Original languageEnglish
Publication statusPublished - 2012
EventMate Poster Award 2012 : 17th Annual Poster Contest -
Duration: 1 Jan 201217 Dec 2012

Conference

ConferenceMate Poster Award 2012 : 17th Annual Poster Contest
Period1/01/1217/12/12
OtherMate Poster Award 2012 : 17th Annual Poster Contest

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Chai, C-K., Akyildiz, A. C., Speelman, L., Gijsen, F. J. H., Oomens, C. W. J., Sambeek, van, M. R. H. M., ... Baaijens, F. P. T. (2012). Local mechanical properties of atherosclerotic plaque tissue. Poster session presented at Mate Poster Award 2012 : 17th Annual Poster Contest, .