Local bone metabolism during the consolidation process of spinal interbody fusion

Arjan C.Y. Loenen; Marloes J.M. Peters; Roel Wierts; Raymond T.J. Bevers; Lodewijk W. van Rhijn; Jacobus J. Arts; Paul C. Willems

doi:10.1007/s00774-021-01281-8

Local bone metabolism during the consolidation process of spinal interbody fusion

Arjan C.Y. Loenen
, Marloes J.M. Peters
, Roel Wierts
, Raymond T.J. Bevers
, Lodewijk W. van Rhijn
, Jacobus J. Arts
, Paul C. Willems (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

53 Downloads (Pure)

Abstract

INTRODUCTION: Although computed tomography (CT) can identify the presence of eventual bony bridges following lumbar interbody fusion (LIF) surgery, it does not provide information on the ongoing formation process of new bony structures. 18F sodium fluoride (18F-NaF) positron emission tomography (PET) could be used as complementary modality to add information on the bone metabolism at the fusion site. However, it remains unknown how bone metabolism in the operated segment changes early after surgery in uncompromised situations. This study aimed to quantify the changes in local bone metabolism during consolidation of LIF.

MATERIALS AND METHODS: Six skeletally mature sheep underwent LIF surgery. 18F-NaF PET/CT scanning was performed 6 and 12 weeks postoperatively to quantify the bone volume and metabolism in the operated segment. Bone metabolism was expressed as a function of bone volume.

RESULTS: Early in the fusion process, bone metabolism was increased at the endplates of the operated vertebrae. In a next phase, bone metabolism increased in the center of the interbody region, peaked, and declined to an equilibrium state. During the entire postoperative time period of 12 weeks, bone metabolism in the interbody region was higher than that of a reference site in the spinal column.

CONCLUSION: Following LIF surgery, there is a rapid increase in bone metabolism at the vertebral endplates that develops towards the center of the interbody region. Knowing the local bone metabolism during uncompromised consolidation of spinal interbody fusion might enable identification of impaired bone formation early after LIF surgery using 18F-NaF PET/CT scanning.

Original language	English
Pages (from-to)	220-228
Number of pages	9
Journal	Journal of Bone and Mineral Metabolism
Volume	40
Issue number	2
Early online date	10 Nov 2021
DOIs	https://doi.org/10.1007/s00774-021-01281-8
Publication status	Published - Mar 2022

Funding

The authors are grateful to the Medanex Clinic team and all personnel of the Maastricht University animal facility for their help and expertise in performing animal studies. The authors would also like to thank the personnel of the department of Radiology and Nuclear Medicine for performing scanning procedures. Additionally, the authors would like to acknowledge Natasja van Dijk (Radboud University Medical Center, Nijmegen) for performing the histology. The research for this paper was financially supported by the Prosperos project, funded by the Interreg VA Flanders—the Netherlands program, CCI grant no. 2014TC16RFCB046.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

F sodium fluoride positron emission tomography
Bone metabolism
Computed tomography
Lumbar interbody fusion
Ovine

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10.1007/s00774-021-01281-8

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Cite this

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title = "Local bone metabolism during the consolidation process of spinal interbody fusion",

abstract = "INTRODUCTION: Although computed tomography (CT) can identify the presence of eventual bony bridges following lumbar interbody fusion (LIF) surgery, it does not provide information on the ongoing formation process of new bony structures. 18F sodium fluoride (18F-NaF) positron emission tomography (PET) could be used as complementary modality to add information on the bone metabolism at the fusion site. However, it remains unknown how bone metabolism in the operated segment changes early after surgery in uncompromised situations. This study aimed to quantify the changes in local bone metabolism during consolidation of LIF.MATERIALS AND METHODS: Six skeletally mature sheep underwent LIF surgery. 18F-NaF PET/CT scanning was performed 6 and 12 weeks postoperatively to quantify the bone volume and metabolism in the operated segment. Bone metabolism was expressed as a function of bone volume.RESULTS: Early in the fusion process, bone metabolism was increased at the endplates of the operated vertebrae. In a next phase, bone metabolism increased in the center of the interbody region, peaked, and declined to an equilibrium state. During the entire postoperative time period of 12 weeks, bone metabolism in the interbody region was higher than that of a reference site in the spinal column.CONCLUSION: Following LIF surgery, there is a rapid increase in bone metabolism at the vertebral endplates that develops towards the center of the interbody region. Knowing the local bone metabolism during uncompromised consolidation of spinal interbody fusion might enable identification of impaired bone formation early after LIF surgery using 18F-NaF PET/CT scanning.",

keywords = "F sodium fluoride positron emission tomography, Bone metabolism, Computed tomography, Lumbar interbody fusion, Ovine",

author = "Loenen, \{Arjan C.Y.\} and Peters, \{Marloes J.M.\} and Roel Wierts and Bevers, \{Raymond T.J.\} and \{van Rhijn\}, \{Lodewijk W.\} and Arts, \{Jacobus J.\} and Willems, \{Paul C.\}",

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year = "2022",

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doi = "10.1007/s00774-021-01281-8",

language = "English",

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T1 - Local bone metabolism during the consolidation process of spinal interbody fusion

AU - Loenen, Arjan C.Y.

AU - Peters, Marloes J.M.

AU - Wierts, Roel

AU - Bevers, Raymond T.J.

AU - van Rhijn, Lodewijk W.

AU - Arts, Jacobus J.

AU - Willems, Paul C.

PY - 2022/3

Y1 - 2022/3

N2 - INTRODUCTION: Although computed tomography (CT) can identify the presence of eventual bony bridges following lumbar interbody fusion (LIF) surgery, it does not provide information on the ongoing formation process of new bony structures. 18F sodium fluoride (18F-NaF) positron emission tomography (PET) could be used as complementary modality to add information on the bone metabolism at the fusion site. However, it remains unknown how bone metabolism in the operated segment changes early after surgery in uncompromised situations. This study aimed to quantify the changes in local bone metabolism during consolidation of LIF.MATERIALS AND METHODS: Six skeletally mature sheep underwent LIF surgery. 18F-NaF PET/CT scanning was performed 6 and 12 weeks postoperatively to quantify the bone volume and metabolism in the operated segment. Bone metabolism was expressed as a function of bone volume.RESULTS: Early in the fusion process, bone metabolism was increased at the endplates of the operated vertebrae. In a next phase, bone metabolism increased in the center of the interbody region, peaked, and declined to an equilibrium state. During the entire postoperative time period of 12 weeks, bone metabolism in the interbody region was higher than that of a reference site in the spinal column.CONCLUSION: Following LIF surgery, there is a rapid increase in bone metabolism at the vertebral endplates that develops towards the center of the interbody region. Knowing the local bone metabolism during uncompromised consolidation of spinal interbody fusion might enable identification of impaired bone formation early after LIF surgery using 18F-NaF PET/CT scanning.

AB - INTRODUCTION: Although computed tomography (CT) can identify the presence of eventual bony bridges following lumbar interbody fusion (LIF) surgery, it does not provide information on the ongoing formation process of new bony structures. 18F sodium fluoride (18F-NaF) positron emission tomography (PET) could be used as complementary modality to add information on the bone metabolism at the fusion site. However, it remains unknown how bone metabolism in the operated segment changes early after surgery in uncompromised situations. This study aimed to quantify the changes in local bone metabolism during consolidation of LIF.MATERIALS AND METHODS: Six skeletally mature sheep underwent LIF surgery. 18F-NaF PET/CT scanning was performed 6 and 12 weeks postoperatively to quantify the bone volume and metabolism in the operated segment. Bone metabolism was expressed as a function of bone volume.RESULTS: Early in the fusion process, bone metabolism was increased at the endplates of the operated vertebrae. In a next phase, bone metabolism increased in the center of the interbody region, peaked, and declined to an equilibrium state. During the entire postoperative time period of 12 weeks, bone metabolism in the interbody region was higher than that of a reference site in the spinal column.CONCLUSION: Following LIF surgery, there is a rapid increase in bone metabolism at the vertebral endplates that develops towards the center of the interbody region. Knowing the local bone metabolism during uncompromised consolidation of spinal interbody fusion might enable identification of impaired bone formation early after LIF surgery using 18F-NaF PET/CT scanning.

KW - F sodium fluoride positron emission tomography

KW - Bone metabolism

KW - Computed tomography

KW - Lumbar interbody fusion

KW - Ovine

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SN - 0914-8779

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SP - 220

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JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

IS - 2

ER -

Local bone metabolism during the consolidation process of spinal interbody fusion

Abstract

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Keywords

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