Liquid-Phase Electron Microscopy for Soft Matter Science and Biology

Hanglong Wu; Heiner Friedrich; Joseph P. Patterson; Nico A.J.M. Sommerdijk; Niels de Jonge

doi:10.1002/adma.202001582

Liquid-Phase Electron Microscopy for Soft Matter Science and Biology

Hanglong Wu, Heiner Friedrich, Joseph P. Patterson, Nico A.J.M. Sommerdijk, Niels de Jonge (Corresponding author)

Research output: Contribution to journal › Article › Academic › peer-review

66 Citations (Scopus)

Abstract

Innovations in liquid-phase electron microscopy (LP-EM) have made it possible to perform experiments at the optimized conditions needed to examine soft matter. The main obstacle is conducting experiments in such a way that electron beam radiation can be used to obtain answers for scientific questions without changing the structure and (bio)chemical processes in the sample due to the influence of the radiation. By overcoming these experimental difficulties at least partially, LP-EM has evolved into a new microscopy method with nanometer spatial resolution and sub-second temporal resolution for analysis of soft matter in materials science and biology. Both experimental design and applications of LP-EM for soft matter materials science and biological research are reviewed, and a perspective of possible future directions is given.

Original language	English
Article number	2001582
Number of pages	21
Journal	Advanced Materials
Volume	32
Issue number	25
DOIs	https://doi.org/10.1002/adma.202001582
Publication status	Published - 1 Jun 2020

Keywords

beam–sample interactions
dynamic processes
in situ electron microscopy
synthetic materials

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10.1002/adma.202001582

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AU - de Jonge, Niels

PY - 2020/6/1

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AB - Innovations in liquid-phase electron microscopy (LP-EM) have made it possible to perform experiments at the optimized conditions needed to examine soft matter. The main obstacle is conducting experiments in such a way that electron beam radiation can be used to obtain answers for scientific questions without changing the structure and (bio)chemical processes in the sample due to the influence of the radiation. By overcoming these experimental difficulties at least partially, LP-EM has evolved into a new microscopy method with nanometer spatial resolution and sub-second temporal resolution for analysis of soft matter in materials science and biology. Both experimental design and applications of LP-EM for soft matter materials science and biological research are reviewed, and a perspective of possible future directions is given.

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Liquid-Phase Electron Microscopy for Soft Matter Science and Biology

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Liquid-Phase Electron Microscopy for Soft Matter Science and Biology

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Center for Multiscale Electron Microscopy (CMEM)

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