Lipidated ras and rab peptides and proteins: synthesis, structure, and function

L. Brunsveld, J. Kuhlmann, K. Alexandrov, A. Wittinghofer, R.S. Goody, H. Waldmann

Research output: Contribution to journalArticleAcademicpeer-review

104 Citations (Scopus)

Abstract

Chemical biology can be defined as the study of biological phenomena from a chemical approach. Based on the analysis of relevant biological phenomena and their structural foundation, unsolved problems are identified and tackled through a combination of chemistry and biology. Thus, new synthetic methods and strategies are developed and employed for the construction of compounds that are used to investigate biological procedures. Solid-phase synthesis has emerged as the preferred method for the synthesis of lipidated peptides, which can be chemoselectively ligated to proteins of the Ras superfamily. The generated peptides and proteins have solved biological questions in the field of the Ras-superfamily GTPases that are not amendable to chemical or biological techniques alone.
Original languageEnglish
Pages (from-to)6622-6646
Number of pages25
JournalAngewandte Chemie - International Edition
Volume45
Issue number40
DOIs
Publication statusPublished - 2006

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