Lipid acrobatics in the membrane fusion arena

A.J. Markvoort, S.J. Marrink

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

52 Citations (Scopus)
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Abstract

In this review, we describe the recent contribution of computer simulation approaches to unravel the molecular details of membrane fusion. Over the past decade, fusion between apposed membranes and vesicles has been studied using a large variety of simulation methods and systems. Despite the variety in techniques, some generic fusion pathways emerge that predict a more complex picture beyond the traditional stalk–pore pathway. Indeed the traditional path-way is confirmed in particle-based simulations, but in addition alternative path-ways are observed in which stalks expand linearly rather than radially, leading to inverted-micellar or asymmetric hemifusion intermediates. Simulations also suggest that the first barrier to fusion is not the formation of the stalk, but rather, the formation of a lipid bridge consisting of one or two lipids only. Fusion occurring during the fission process involves other intermediates, however, and is not just fusion reversed. Finally, recent progress in simulations of peptide and protein-mediated fusion shows how fusion proceeds in a more biologically relevant scenario.
Original languageEnglish
Title of host publicationMembrane Fusion
EditorsM.M. Kozlov, L.V. Chernomordik
Place of PublicationNew York
PublisherElsevier
Pages259-294
ISBN (Print)978-0-12-385891-7
DOIs
Publication statusPublished - 2011

Publication series

NameCurrent Topics on Membranes
Volume68

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  • Cite this

    Markvoort, A. J., & Marrink, S. J. (2011). Lipid acrobatics in the membrane fusion arena. In M. M. Kozlov, & L. V. Chernomordik (Eds.), Membrane Fusion (pp. 259-294). (Current Topics on Membranes; Vol. 68). Elsevier. https://doi.org/10.1016/B978-0-12-385891-7.00011-8