Abstract
According to present knowledge, the Ni-catalyzed hydrocyanation of styrene leads predominantly to the branched product 2-phenylpropionitrile (98%). We observed a dramatic inversion of the regioselectivity upon addition of a Lewis acid. Up to 83 % of the linear product 3-phenylpropionitrile was obtained by applying phosphite Iigands in the presence of AlCl3. The mechanism of the Ni-catalyzed reaction and the influence of additional Lewis acids have been investigated by means of deuterium labeling experiments, NMR studies, and DFT calculations. Furthermore, the behavior of different Lewis acids, such as CuCN, could be rationalized and predicted by DFT calculations. © 2009 Wiley-VCH Verlag GmbH & Cu. KGaA.
| Original language | English |
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| Pages (from-to) | 8768-8778 |
| Journal | Chemistry : A European Journal |
| Volume | 15 |
| Issue number | 35 |
| DOIs | |
| Publication status | Published - 2009 |