Leaching-free supported gold nanoparticles catalyzing cycloisomerizations under microflow conditions

F.S. Schroeder; N. Erdmann; T. Noël; R. Luque; E.V. Eycken, van der

doi:10.1002/adsc.201500628

Leaching-free supported gold nanoparticles catalyzing cycloisomerizations under microflow conditions

F.S. Schroeder, N. Erdmann, T. Noël, R. Luque, E.V. Eycken, van der

Micro Flow Chemistry and Synthetic Methodology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A continuous-flow protocol for the gold-catalyzed cycloisomerization of sterically hindered Ugi-adducts to spiroindolines in a packed-bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected.

Original language	English
Pages (from-to)	3141-3147
Journal	Advanced Synthesis & Catalysis
Volume	357
Issue number	14-15
DOIs	https://doi.org/10.1002/adsc.201500628
Publication status	Published - 2015

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title = "Leaching-free supported gold nanoparticles catalyzing cycloisomerizations under microflow conditions",

abstract = "A continuous-flow protocol for the gold-catalyzed cycloisomerization of sterically hindered Ugi-adducts to spiroindolines in a packed-bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected.",

author = "F.S. Schroeder and N. Erdmann and T. No{\"e}l and R. Luque and {Eycken, van der}, E.V.",

year = "2015",

doi = "10.1002/adsc.201500628",

language = "English",

volume = "357",

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T1 - Leaching-free supported gold nanoparticles catalyzing cycloisomerizations under microflow conditions

AU - Schroeder, F.S.

AU - Erdmann, N.

AU - Noël, T.

AU - Luque, R.

AU - Eycken, van der, E.V.

PY - 2015

Y1 - 2015

N2 - A continuous-flow protocol for the gold-catalyzed cycloisomerization of sterically hindered Ugi-adducts to spiroindolines in a packed-bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected.

AB - A continuous-flow protocol for the gold-catalyzed cycloisomerization of sterically hindered Ugi-adducts to spiroindolines in a packed-bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected.

U2 - 10.1002/adsc.201500628

DO - 10.1002/adsc.201500628

M3 - Article

SN - 1615-4150

VL - 357

SP - 3141

EP - 3147

JO - Advanced Synthesis & Catalysis

JF - Advanced Synthesis & Catalysis

IS - 14-15

ER -

Leaching-free supported gold nanoparticles catalyzing cycloisomerizations under microflow conditions

Abstract

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