Leaching-free supported gold nanoparticles catalyzing cycloisomerizations under microflow conditions

F.S. Schroeder, N. Erdmann, T. Noël, R. Luque, E.V. Eycken, van der

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
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Abstract

A continuous-flow protocol for the gold-catalyzed cycloisomerization of sterically hindered Ugi-adducts to spiroindolines in a packed-bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected.
Original languageEnglish
Pages (from-to)3141-3147
JournalAdvanced Synthesis & Catalysis
Volume357
Issue number14-15
DOIs
Publication statusPublished - 2015

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