Lateral diffusion in lipid membranes through collective flows

E. Falck, T. Róg, M.E.J. Karttunen, I. Vattulainen

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    119 Citations (Scopus)
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    Abstract

    There is no comprehensive model for the dynamics of cellular membranes. Even mechanisms of basic dynamic processes, such as lateral diffusion of lipids, are poorly understood. Our atomic-scale molecular dynamics simulations support a novel, concerted mechanism for lipid diffusion. We find that a lipid and its nearest neighbors move in unison, forming loosely defined clusters. What is more, the motions of lipids are correlated over tens of nanometers:¿ the lateral displacements of lipids in a given monolayer produce striking two-dimensional flow patterns. These flow patterns should have wide implications, affecting, for example, the formation of membrane domains, protein functionality, and action of lipases and drugs on membranes.
    Original languageEnglish
    Pages (from-to)44-45
    Number of pages2
    JournalJournal of the American Chemical Society
    Volume130
    Issue number1
    DOIs
    Publication statusPublished - 2008

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