The purpose of the following analysis is to identify the most promising organisational strategies of innovative agents under different environmental constraints. To do so, the processes of the relationships between these agents are taken into account by putting three aspects together. First, it is shown that the transfer, storage, and use of knowledge are significantly influenced by this knowledge's characteristics. Second, the main principles of the generation and selection of innovation are introduced from the systemic point of view. As a third element, the variety of possible relationships between innovative agents are categorised to identify the different organisational principles that can be employed. By putting all these elements together, it is possible to show which strategies are the most promising under different constraints given by the innovation possibilities, the relevant institutions, the knowledge employed, and the kind of innovation expected.