Abstract
Dynamic contrast-enhanced (DCE) MRI plays an essential role for cancer detection and characterization. Ideally, DCE-MRI data would be acquired with high spatial and high temporal resolution to fully exploit both the morphologic and kinetic information. However, for DCE-MRI of the breast, temporal resolution is often in the range of 1–2 minutes, due to technical constraints. So far, this low temporal resolution has hampered widespread implementation of advanced kinetic modeling into clinical breast cancer screening practice. The model applied in this study describes the exchange of contrast agent between the input in the blood plasma and the uptake in the tissue. We systematically analyzed the influence of temporal resolution on the estimates of the modeling parameters (Ktrans, ve). We used high-temporal-resolution data (5 s) of an animal tumor model as the basis for our simulation study.
| Original language | English |
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| Title of host publication | Proceedings of the NVPHBV Spring Meeting 2009, 29 May 2009, Amsterdam, The Netherlands |
| Place of Publication | Netherlands, Amsterdam |
| Publication status | Published - 2009 |
