Janus nanocarrier powered by bi-enzymatic cascade system for smart delivery

Sandra Jimenez-Falcao; Natalia Joga; Alba García-Fernández; Antoni Llopis Lorente; Daniel Torres; Beatriz De Luis; Félix Sancenón; Paloma Martínez-Ruiz; Ramón Martínez-Máñez; Reynaldo Villalonga

doi:10.1039/c9tb00938h

Janus nanocarrier powered by bi-enzymatic cascade system for smart delivery

Sandra Jimenez-Falcao, Natalia Joga, Alba García-Fernández, Antoni Llopis Lorente, Daniel Torres, Beatriz De Luis, Félix Sancenón, Paloma Martínez-Ruiz, Ramón Martínez-Máñez, Reynaldo Villalonga

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

We report herein the assembly of an integrated nanodevice with bi-enzymatic cascade control for on-command cargo release. This nanocarrier is based on Au-mesoporous silica Janus nanoparticles capped at the mesoporous face with benzimidazole/β-cyclodextrin-glucose oxidase pH-sensitive gate-like ensembles and functionalized with invertase on the gold face. The rationale for this delivery mechanism is based on the invertase-mediated hydrolysis of sucrose yielding glucose, which is further transformed into gluconic acid by glucose oxidase causing the disruption of the pH-sensitive supramolecular gates at the Janus nanoparticles. This enzyme-powered device was successfully employed in the autonomous and on-demand delivery of doxorubicin in HeLa cancer cells.

Original language	English
Pages (from-to)	4669-4676
Number of pages	8
Journal	Journal of Materials Chemistry B
Volume	7
Issue number	30
DOIs	https://doi.org/10.1039/c9tb00938h
Publication status	Published - 31 Jul 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c9tb00938h

Cite this

@article{9c7fcb43a9de40b48a17ac09c6b236c9,

title = "Janus nanocarrier powered by bi-enzymatic cascade system for smart delivery",

abstract = "We report herein the assembly of an integrated nanodevice with bi-enzymatic cascade control for on-command cargo release. This nanocarrier is based on Au-mesoporous silica Janus nanoparticles capped at the mesoporous face with benzimidazole/β-cyclodextrin-glucose oxidase pH-sensitive gate-like ensembles and functionalized with invertase on the gold face. The rationale for this delivery mechanism is based on the invertase-mediated hydrolysis of sucrose yielding glucose, which is further transformed into gluconic acid by glucose oxidase causing the disruption of the pH-sensitive supramolecular gates at the Janus nanoparticles. This enzyme-powered device was successfully employed in the autonomous and on-demand delivery of doxorubicin in HeLa cancer cells.",

author = "Sandra Jimenez-Falcao and Natalia Joga and Alba Garc{\'i}a-Fern{\'a}ndez and {Llopis Lorente}, Antoni and Daniel Torres and {De Luis}, Beatriz and F{\'e}lix Sancen{\'o}n and Paloma Mart{\'i}nez-Ruiz and Ram{\'o}n Mart{\'i}nez-M{\'a}{\~n}ez and Reynaldo Villalonga",

year = "2019",

month = jul,

day = "31",

doi = "10.1039/c9tb00938h",

language = "English",

volume = "7",

pages = "4669--4676",

journal = "Journal of Materials Chemistry B",

issn = "2050-750X",

publisher = "Royal Society of Chemistry",

number = "30",

}

TY - JOUR

T1 - Janus nanocarrier powered by bi-enzymatic cascade system for smart delivery

AU - Jimenez-Falcao, Sandra

AU - Joga, Natalia

AU - García-Fernández, Alba

AU - Llopis Lorente, Antoni

AU - Torres, Daniel

AU - De Luis, Beatriz

AU - Sancenón, Félix

AU - Martínez-Ruiz, Paloma

AU - Martínez-Máñez, Ramón

AU - Villalonga, Reynaldo

PY - 2019/7/31

Y1 - 2019/7/31

N2 - We report herein the assembly of an integrated nanodevice with bi-enzymatic cascade control for on-command cargo release. This nanocarrier is based on Au-mesoporous silica Janus nanoparticles capped at the mesoporous face with benzimidazole/β-cyclodextrin-glucose oxidase pH-sensitive gate-like ensembles and functionalized with invertase on the gold face. The rationale for this delivery mechanism is based on the invertase-mediated hydrolysis of sucrose yielding glucose, which is further transformed into gluconic acid by glucose oxidase causing the disruption of the pH-sensitive supramolecular gates at the Janus nanoparticles. This enzyme-powered device was successfully employed in the autonomous and on-demand delivery of doxorubicin in HeLa cancer cells.

AB - We report herein the assembly of an integrated nanodevice with bi-enzymatic cascade control for on-command cargo release. This nanocarrier is based on Au-mesoporous silica Janus nanoparticles capped at the mesoporous face with benzimidazole/β-cyclodextrin-glucose oxidase pH-sensitive gate-like ensembles and functionalized with invertase on the gold face. The rationale for this delivery mechanism is based on the invertase-mediated hydrolysis of sucrose yielding glucose, which is further transformed into gluconic acid by glucose oxidase causing the disruption of the pH-sensitive supramolecular gates at the Janus nanoparticles. This enzyme-powered device was successfully employed in the autonomous and on-demand delivery of doxorubicin in HeLa cancer cells.

UR - http://www.scopus.com/inward/record.url?scp=85070100214&partnerID=8YFLogxK

U2 - 10.1039/c9tb00938h

DO - 10.1039/c9tb00938h

M3 - Article

C2 - 31364688

AN - SCOPUS:85070100214

SN - 2050-750X

VL - 7

SP - 4669

EP - 4676

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 30

ER -

Janus nanocarrier powered by bi-enzymatic cascade system for smart delivery

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this