Janus gold nanostars–mesoporous silica nanoparticles for NIR-light-triggered drug delivery

Andy Hernández Montoto; Antoni Llopis-Lorente; Mónica Gorbe; José M. Terrés; Roberto Cao-Milán; Borja Díaz de Greñu; María Alfonso; Javier Ibañez; María D. Marcos; Mar Orzáez; Reynaldo Villalonga; Ramón Martínez-Máñez; Félix Sancenón

doi:10.1002/chem.201900750

Janus gold nanostars–mesoporous silica nanoparticles for NIR-light-triggered drug delivery

Andy Hernández Montoto
, Antoni Llopis-Lorente
, Mónica Gorbe
, José M. Terrés
, Roberto Cao-Milán
, Borja Díaz de Greñu
, María Alfonso
, Javier Ibañez
, María D. Marcos
, Mar Orzáez
, Reynaldo Villalonga
, Ramón Martínez-Máñez (Corresponding author)
, Félix Sancenón

Research output: Contribution to journal › Article › Academic › peer-review

48 Citations (Scopus)

Abstract

Janus gold nanostar–mesoporous silica nanoparticle (AuNSt–MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was functionalized with a thiolated photolabile molecule (5), whereas the mesoporous silica face was loaded with a model drug (doxorubicin) and capped with proton-responsive benzimidazole-β-cyclodextrin supramolecular gatekeepers (N 1). Upon irradiation with NIR-light, the photolabile compound 5 photodissociated, resulting in the formation of succinic acid, which induced the opening of the gatekeeper and cargo delivery. In the overall mechanism, the gold surface acts as a photochemical transducer capable of transforming the NIR-light input into a chemical messenger (succinic acid) that opens the supramolecular nanovalve. The prepared hybrid nanoparticles were non-cytotoxic to HeLa cells, until they were irradiated with a NIR laser, which led to intracellular doxorubicin release and hyperthermia. This induced a remarkable reduction in HeLa cells viability.

Original language	English
Pages (from-to)	8471-8478
Number of pages	8
Journal	Chemistry : A European Journal
Volume	25
Issue number	36
DOIs	https://doi.org/10.1002/chem.201900750
Publication status	Published - 26 Jun 2019
Externally published	Yes

Funding

The authors gratefully acknowledge financial support from the Spanish Government [Projects MAT2015-64139-C4-1-R, AGL2015-70235-C2-2-R and SAF2017-84689-R (MINECO/AEI/ FEDER, UE)], the Generalitat Valenciana (Project PROME-TEO2018/024) and European Union (Erasmus Mundus Programme, Action 2, grant agreement number 2014-0870/001-001). A.H. thanks the Erasmus Mundus Programme for his PhD scholarship through the EuroInkaNet project. A.L.-L. thanks “La Caixa” Banking Foundation for his PhD scholarship. The authors thank the electron microscopy, CIPF confocal, and electron microscopy services of the UPV for technical support.

Keywords

drug delivery
gold
light-responsive nanodevices
mesoporous silica
NIR light
Silicon Dioxide/chemistry
Nanostructures/chemistry
Humans
Cell Survival/drug effects
Doxorubicin/chemistry
Gold/chemistry
Microscopy, Confocal
Drug Carriers/chemistry
Infrared Rays
Hyperthermia, Induced
Porosity

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10.1002/chem.201900750

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Hernández Montoto, A., Llopis-Lorente, A., Gorbe, M., M. Terrés, J., Cao-Milán, R., Díaz de Greñu, B., Alfonso, M., Ibañez, J., Marcos, M. D., Orzáez, M., Villalonga, R., Martínez-Máñez, R., & Sancenón, F. (2019). Janus gold nanostars–mesoporous silica nanoparticles for NIR-light-triggered drug delivery. Chemistry : A European Journal, 25(36), 8471-8478. https://doi.org/10.1002/chem.201900750

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title = "Janus gold nanostars–mesoporous silica nanoparticles for NIR-light-triggered drug delivery",

abstract = "Janus gold nanostar–mesoporous silica nanoparticle (AuNSt–MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was functionalized with a thiolated photolabile molecule (5), whereas the mesoporous silica face was loaded with a model drug (doxorubicin) and capped with proton-responsive benzimidazole-β-cyclodextrin supramolecular gatekeepers (N 1). Upon irradiation with NIR-light, the photolabile compound 5 photodissociated, resulting in the formation of succinic acid, which induced the opening of the gatekeeper and cargo delivery. In the overall mechanism, the gold surface acts as a photochemical transducer capable of transforming the NIR-light input into a chemical messenger (succinic acid) that opens the supramolecular nanovalve. The prepared hybrid nanoparticles were non-cytotoxic to HeLa cells, until they were irradiated with a NIR laser, which led to intracellular doxorubicin release and hyperthermia. This induced a remarkable reduction in HeLa cells viability.",

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Hernández Montoto, A, Llopis-Lorente, A, Gorbe, M, M. Terrés, J, Cao-Milán, R, Díaz de Greñu, B, Alfonso, M, Ibañez, J, Marcos, MD, Orzáez, M, Villalonga, R, Martínez-Máñez, R & Sancenón, F 2019, 'Janus gold nanostars–mesoporous silica nanoparticles for NIR-light-triggered drug delivery', Chemistry : A European Journal, vol. 25, no. 36, pp. 8471-8478. https://doi.org/10.1002/chem.201900750

TY - JOUR

T1 - Janus gold nanostars–mesoporous silica nanoparticles for NIR-light-triggered drug delivery

AU - Hernández Montoto, Andy

AU - Llopis-Lorente, Antoni

AU - Gorbe, Mónica

AU - M. Terrés, José

AU - Cao-Milán, Roberto

AU - Díaz de Greñu, Borja

AU - Alfonso, María

AU - Ibañez, Javier

AU - Marcos, María D.

AU - Orzáez, Mar

AU - Villalonga, Reynaldo

AU - Martínez-Máñez, Ramón

AU - Sancenón, Félix

PY - 2019/6/26

Y1 - 2019/6/26

N2 - Janus gold nanostar–mesoporous silica nanoparticle (AuNSt–MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was functionalized with a thiolated photolabile molecule (5), whereas the mesoporous silica face was loaded with a model drug (doxorubicin) and capped with proton-responsive benzimidazole-β-cyclodextrin supramolecular gatekeepers (N 1). Upon irradiation with NIR-light, the photolabile compound 5 photodissociated, resulting in the formation of succinic acid, which induced the opening of the gatekeeper and cargo delivery. In the overall mechanism, the gold surface acts as a photochemical transducer capable of transforming the NIR-light input into a chemical messenger (succinic acid) that opens the supramolecular nanovalve. The prepared hybrid nanoparticles were non-cytotoxic to HeLa cells, until they were irradiated with a NIR laser, which led to intracellular doxorubicin release and hyperthermia. This induced a remarkable reduction in HeLa cells viability.

AB - Janus gold nanostar–mesoporous silica nanoparticle (AuNSt–MSNP) nanodevices able to release an entrapped payload upon irradiation with near infrared (NIR) light were prepared and characterized. The AuNSt surface was functionalized with a thiolated photolabile molecule (5), whereas the mesoporous silica face was loaded with a model drug (doxorubicin) and capped with proton-responsive benzimidazole-β-cyclodextrin supramolecular gatekeepers (N 1). Upon irradiation with NIR-light, the photolabile compound 5 photodissociated, resulting in the formation of succinic acid, which induced the opening of the gatekeeper and cargo delivery. In the overall mechanism, the gold surface acts as a photochemical transducer capable of transforming the NIR-light input into a chemical messenger (succinic acid) that opens the supramolecular nanovalve. The prepared hybrid nanoparticles were non-cytotoxic to HeLa cells, until they were irradiated with a NIR laser, which led to intracellular doxorubicin release and hyperthermia. This induced a remarkable reduction in HeLa cells viability.

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KW - light-responsive nanodevices

KW - mesoporous silica

KW - NIR light

KW - Silicon Dioxide/chemistry

KW - Nanostructures/chemistry

KW - Humans

KW - Cell Survival/drug effects

KW - Doxorubicin/chemistry

KW - Gold/chemistry

KW - Microscopy, Confocal

KW - Drug Carriers/chemistry

KW - Infrared Rays

KW - Hyperthermia, Induced

KW - Porosity

UR - https://www.scopus.com/pages/publications/85068785772

U2 - 10.1002/chem.201900750

DO - 10.1002/chem.201900750

M3 - Article

C2 - 31012155

AN - SCOPUS:85068785772

SN - 0947-6539

VL - 25

SP - 8471

EP - 8478

JO - Chemistry : A European Journal

JF - Chemistry : A European Journal

IS - 36

ER -

Janus gold nanostars–mesoporous silica nanoparticles for NIR-light-triggered drug delivery

Abstract

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Keywords

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