Iron-catalyzed cross-coupling of alkynyl and styrenyl chlorides with alkyl grignard reagents in batch and flow

Yuchao Deng, Xiao Jing Wei, Xiao Wang, Yuhan Sun, Timothy Noël (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)
57 Downloads (Pure)

Abstract

Transition-metal-catalyzed cross-coupling chemistry can be regarded as one of the most powerful protocols to construct carbon-carbon bonds. While the field is still dominated by palladium catalysis, there is an increasing interest to develop protocols that utilize cheaper and more sustainable metal sources. Herein, we report a selective, practical, and fast iron-based cross-coupling reaction that enables the formation of Csp-Csp3 and Csp2 -Csp3 bonds. In a telescoped flow process, the reaction can be combined with the Grignard reagent synthesis. Moreover, flow allows the use of a supporting ligand to be avoided without eroding the reaction selectivity.

Original languageEnglish
Pages (from-to)14532-14535
Number of pages4
JournalChemistry : A European Journal
Volume25
Issue number64
DOIs
Publication statusPublished - 18 Nov 2019

Keywords

  • catalysis
  • cross-coupling
  • flow chemistry
  • Grignard reagents
  • iron

Fingerprint

Dive into the research topics of 'Iron-catalyzed cross-coupling of alkynyl and styrenyl chlorides with alkyl grignard reagents in batch and flow'. Together they form a unique fingerprint.

Cite this