Iridium(I)-catalyzed ortho-directed hydrogen isotope exchange in continuous-flow reactors

E.R.M. Habraken, P. Haspeslagh, M. Vliegen, T. Noel

Research output: Contribution to journalArticleAcademicpeer-review

12 Citations (Scopus)


Deuterated compounds are important in drug discovery and development, e.g., to prepare the so-called stable isotopically labeled internal standards. However, their preparation can be challenging, and its scalability could be difficult with regard to safety aspects. Herein, we report the first continuous-flow iridium(I)-catalyzed ortho-directed hydrogen–deuterium exchange reaction in microreactors. An immobilized iridium(I) catalyst was loaded in continuous-flow microreactors, such as continuous stirred tank reactors and packed-bed reactors. Best results were obtained in a packed-bed reactor allowing deuterium labeling up to M +7.
Original languageEnglish
Pages (from-to)2-5
JournalJournal of Flow Chemistry
Issue number1
Publication statusPublished - 2015


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