Investigation on the effect of spatial compounding on photoacoustic images of carotid plaques in the in vivo available rotational range

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Abstract

Photoacoustic imaging (PA) is a promising imaging modality due to its high optical specificity. However, the low signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of in vivo PA images are major challenges that prevent PA imaging from finding its place in clinics. This study investigates the merit of spatial compounding of PA images in arterial phantoms and the achievable improvements of SNR when in vivo conditions are mimicked. The analysis of the compounding technique was performed on a polyvinyl alcohol vessel phantom with black threads embedded in its wall. The in vivo conditions were mimicked by limiting the rotation range in ± 30°, adding turbid surrounding medium, and filling the lumen with porcine blood. Finally, the performance of the technique was evaluated in ex vivo human carotid plaque samples. Results showed that spatial compounding elevates the SNR by 5 to 10 dB and CNR by 1 to 5, depending on the location of the absorbers. This study elucidates prospective in vivo PA characterization of carotid plaques by proposing a method to enhance PA image quality.

Original languageEnglish
Pages (from-to)440-447
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume65
Issue number3
DOIs
Publication statusPublished - 11 Jan 2018

Fingerprint

compounding
Photoacoustic effect
signal to noise ratios
Imaging techniques
lumens
polyvinyl alcohol
threads
Signal to noise ratio
blood
vessels
absorbers
Polyvinyl alcohols
Acoustic noise
Image quality
Blood

Keywords

  • Acoustics
  • carotid plaques
  • Frequency control
  • In vivo
  • Phantoms
  • Photoacoustic imaging
  • Probes
  • Signal to noise ratio
  • spatial compounding
  • ultrasound

Cite this

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title = "Investigation on the effect of spatial compounding on photoacoustic images of carotid plaques in the in vivo available rotational range",
abstract = "Photoacoustic imaging (PA) is a promising imaging modality due to its high optical specificity. However, the low signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of in vivo PA images are major challenges that prevent PA imaging from finding its place in clinics. This study investigates the merit of spatial compounding of PA images in arterial phantoms and the achievable improvements of SNR when in vivo conditions are mimicked. The analysis of the compounding technique was performed on a polyvinyl alcohol vessel phantom with black threads embedded in its wall. The in vivo conditions were mimicked by limiting the rotation range in ± 30°, adding turbid surrounding medium, and filling the lumen with porcine blood. Finally, the performance of the technique was evaluated in ex vivo human carotid plaque samples. Results showed that spatial compounding elevates the SNR by 5 to 10 dB and CNR by 1 to 5, depending on the location of the absorbers. This study elucidates prospective in vivo PA characterization of carotid plaques by proposing a method to enhance PA image quality.",
keywords = "Acoustics, carotid plaques, Frequency control, In vivo, Phantoms, Photoacoustic imaging, Probes, Signal to noise ratio, spatial compounding, ultrasound",
author = "M.U. Arabul and H.M. Heres and M.C.M. Rutten and {van Sambeek}, M.R.H.M. and {van de Vosse}, F.N. and R.G.P. Lopata",
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AU - Heres, H.M.

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AU - van Sambeek, M.R.H.M.

AU - van de Vosse, F.N.

AU - Lopata, R.G.P.

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N2 - Photoacoustic imaging (PA) is a promising imaging modality due to its high optical specificity. However, the low signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of in vivo PA images are major challenges that prevent PA imaging from finding its place in clinics. This study investigates the merit of spatial compounding of PA images in arterial phantoms and the achievable improvements of SNR when in vivo conditions are mimicked. The analysis of the compounding technique was performed on a polyvinyl alcohol vessel phantom with black threads embedded in its wall. The in vivo conditions were mimicked by limiting the rotation range in ± 30°, adding turbid surrounding medium, and filling the lumen with porcine blood. Finally, the performance of the technique was evaluated in ex vivo human carotid plaque samples. Results showed that spatial compounding elevates the SNR by 5 to 10 dB and CNR by 1 to 5, depending on the location of the absorbers. This study elucidates prospective in vivo PA characterization of carotid plaques by proposing a method to enhance PA image quality.

AB - Photoacoustic imaging (PA) is a promising imaging modality due to its high optical specificity. However, the low signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of in vivo PA images are major challenges that prevent PA imaging from finding its place in clinics. This study investigates the merit of spatial compounding of PA images in arterial phantoms and the achievable improvements of SNR when in vivo conditions are mimicked. The analysis of the compounding technique was performed on a polyvinyl alcohol vessel phantom with black threads embedded in its wall. The in vivo conditions were mimicked by limiting the rotation range in ± 30°, adding turbid surrounding medium, and filling the lumen with porcine blood. Finally, the performance of the technique was evaluated in ex vivo human carotid plaque samples. Results showed that spatial compounding elevates the SNR by 5 to 10 dB and CNR by 1 to 5, depending on the location of the absorbers. This study elucidates prospective in vivo PA characterization of carotid plaques by proposing a method to enhance PA image quality.

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