Investigation on the effect of spatial compounding on photoacoustic images of carotid plaques in the in vivo available rotational range

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)
107 Downloads (Pure)

Abstract

Photoacoustic imaging (PAI) is a promising imaging modality due to its high optical specificity. However, the low signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of in vivo PA images are major challenges that prevent PAI from finding its place in clinics. This paper investigates the merit of spatial compounding of PA images in arterial phantoms and the achievable improvements of SNR, when in vivo conditions are mimicked. The analysis of the compounding technique was performed on a polyvinyl alcohol vessel phantom with black threads embedded in its wall. The in vivo conditions were mimicked by limiting the rotation range in ±30°, adding turbid surrounding medium, and filling the lumen with porcine blood. Finally, the performance of the technique was evaluated in ex vivo human carotid plaque samples. Results showed that spatial compounding elevates the SNR by 5-10 dB and CNR by 1-5 dB, depending on the location of the absorbers. This paper elucidates prospective in vivo PA characterization of carotid plaques by proposing a method to enhance PA image quality.

Original languageEnglish
Pages (from-to)440-447
Number of pages8
JournalIEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Volume65
Issue number3
DOIs
Publication statusPublished - Mar 2018

Keywords

  • Acoustics
  • carotid plaques
  • Frequency control
  • In vivo
  • Phantoms
  • Photoacoustic imaging
  • Probes
  • Signal to noise ratio
  • spatial compounding
  • ultrasound
  • Carotid plaques
  • photoacoustic imaging (PAI)
  • ultrasound (US)
  • Plaque, Atherosclerotic/diagnostic imaging
  • Humans
  • Carotid Arteries/diagnostic imaging
  • Animals
  • Swine
  • Ultrasonography
  • Carotid Stenosis
  • Image Interpretation, Computer-Assisted/methods
  • Phantoms, Imaging
  • Photoacoustic Techniques/methods

Fingerprint Dive into the research topics of 'Investigation on the effect of spatial compounding on photoacoustic images of carotid plaques in the in vivo available rotational range'. Together they form a unique fingerprint.

Cite this