Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions

Imke Pijpers, Fenghua Meng, Jan van Hest (Corresponding author), Loai Abdelmohsen (Corresponding author)

Research output: Contribution to journalArticleAcademicpeer-review

6 Downloads (Pure)

Abstract

The assembly of amphiphilic block copolymers in well-defined polymer nanoparticles is an intricate interplay between polymer composition, method of assembly and the properties of the organic solvent used to dissolve the polymer building blocks. Remarkably, the role of organic solvent composition has been much less studied in comparison to the other two parameters. Here we have systematically investigated the effect of organic solvent composition, namely, the ratio between tetrahydrofuran and dioxane, on the self-assembly of PEG-PDLLA copolymers into polymer vesicles and their subsequent shape change in different topologies. Uncovering such physical basis unlocks new opportunities for the development of complex nanoparticles without the need of extended polymer engineering processes.
Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalPolymer Chemistry
Volume11
Issue number2
DOIs
Publication statusPublished - 14 Jan 2020

Fingerprint

Ethylene Glycol
Self assembly
Polyethylene glycols
Polymers
Organic solvents
Nanoparticles
Chemical analysis
Block copolymers
Copolymers
Topology
dilactide

Cite this

@article{b422f5dc89704c819318f1cde4fd3b3d,
title = "Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions",
abstract = "The assembly of amphiphilic block copolymers in well-defined polymer nanoparticles is an intricate interplay between polymer composition, method of assembly and the properties of the organic solvent used to dissolve the polymer building blocks. Remarkably, the role of organic solvent composition has been much less studied in comparison to the other two parameters. Here we have systematically investigated the effect of organic solvent composition, namely, the ratio between tetrahydrofuran and dioxane, on the self-assembly of PEG-PDLLA copolymers into polymer vesicles and their subsequent shape change in different topologies. Uncovering such physical basis unlocks new opportunities for the development of complex nanoparticles without the need of extended polymer engineering processes.",
author = "Imke Pijpers and Fenghua Meng and {van Hest}, Jan and Loai Abdelmohsen",
year = "2020",
month = "1",
day = "14",
doi = "10.1039/C9PY01089K",
language = "English",
volume = "11",
pages = "275--280",
journal = "Polymer Chemistry",
issn = "1759-9954",
publisher = "Royal Society of Chemistry",
number = "2",

}

TY - JOUR

T1 - Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions

AU - Pijpers, Imke

AU - Meng, Fenghua

AU - van Hest, Jan

AU - Abdelmohsen, Loai

PY - 2020/1/14

Y1 - 2020/1/14

N2 - The assembly of amphiphilic block copolymers in well-defined polymer nanoparticles is an intricate interplay between polymer composition, method of assembly and the properties of the organic solvent used to dissolve the polymer building blocks. Remarkably, the role of organic solvent composition has been much less studied in comparison to the other two parameters. Here we have systematically investigated the effect of organic solvent composition, namely, the ratio between tetrahydrofuran and dioxane, on the self-assembly of PEG-PDLLA copolymers into polymer vesicles and their subsequent shape change in different topologies. Uncovering such physical basis unlocks new opportunities for the development of complex nanoparticles without the need of extended polymer engineering processes.

AB - The assembly of amphiphilic block copolymers in well-defined polymer nanoparticles is an intricate interplay between polymer composition, method of assembly and the properties of the organic solvent used to dissolve the polymer building blocks. Remarkably, the role of organic solvent composition has been much less studied in comparison to the other two parameters. Here we have systematically investigated the effect of organic solvent composition, namely, the ratio between tetrahydrofuran and dioxane, on the self-assembly of PEG-PDLLA copolymers into polymer vesicles and their subsequent shape change in different topologies. Uncovering such physical basis unlocks new opportunities for the development of complex nanoparticles without the need of extended polymer engineering processes.

UR - http://www.scopus.com/inward/record.url?scp=85077625330&partnerID=8YFLogxK

U2 - 10.1039/C9PY01089K

DO - 10.1039/C9PY01089K

M3 - Article

VL - 11

SP - 275

EP - 280

JO - Polymer Chemistry

JF - Polymer Chemistry

SN - 1759-9954

IS - 2

ER -