Investigating supramolecular systems using Förster resonance energy transfer

Abraham J.P. Teunissen, Carlos Pérez-Medina, Andries Meijerink, Willem J.M. Mulder

Research output: Contribution to journalReview articleAcademicpeer-review

11 Citations (Scopus)

Abstract

Supramolecular systems have applications in areas as diverse as materials science, biochemistry, analytical chemistry, and nanomedicine. However, analyzing such systems can be challenging due to the wide range of time scales, binding strengths, distances, and concentrations at which non-covalent phenomena take place. Due to their versatility and sensitivity, Förster resonance energy transfer (FRET)-based techniques are excellently suited to meet such challenges. Here, we detail the ways in which FRET has been used to study non-covalent interactions in both synthetic and biological supramolecular systems. Among other topics, we examine methods to measure molecular forces, determine protein conformations, monitor assembly kinetics, and visualize in vivo drug release from nanoparticles. Furthermore, we highlight multiplex FRET techniques, discuss the field's limitations, and provide a perspective on new developments.

LanguageEnglish
Pages7027-7044
Number of pages18
JournalChemical Society Reviews
Volume47
Issue number18
DOIs
StatePublished - 21 Sep 2018

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Energy transfer
Medical nanotechnology
Biochemistry
Materials science
Conformations
Nanoparticles
Kinetics
Chemical analysis
Pharmaceutical Preparations
Proteins

Cite this

Teunissen, Abraham J.P. ; Pérez-Medina, Carlos ; Meijerink, Andries ; Mulder, Willem J.M./ Investigating supramolecular systems using Förster resonance energy transfer. In: Chemical Society Reviews. 2018 ; Vol. 47, No. 18. pp. 7027-7044
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Teunissen, AJP, Pérez-Medina, C, Meijerink, A & Mulder, WJM 2018, 'Investigating supramolecular systems using Förster resonance energy transfer' Chemical Society Reviews, vol. 47, no. 18, pp. 7027-7044. DOI: 10.1039/c8cs00278a

Investigating supramolecular systems using Förster resonance energy transfer. / Teunissen, Abraham J.P.; Pérez-Medina, Carlos; Meijerink, Andries; Mulder, Willem J.M.

In: Chemical Society Reviews, Vol. 47, No. 18, 21.09.2018, p. 7027-7044.

Research output: Contribution to journalReview articleAcademicpeer-review

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Teunissen AJP, Pérez-Medina C, Meijerink A, Mulder WJM. Investigating supramolecular systems using Förster resonance energy transfer. Chemical Society Reviews. 2018 Sep 21;47(18):7027-7044. Available from, DOI: 10.1039/c8cs00278a