Intraplaque haemorrhage detection using single-wavelength PAI and singular value decomposition in the carotid artery

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The rupture of a vulnerable carotid plaque featuring a lipid-rich necrotic core and intra-plaque haemorrhages is the major cause of stroke. Photoacoustic imaging (PAI) is a promising technique for assessing plaque vulnerability in the carotid artery due to its ability to assess the chemical composition in addition to its anatomy. However, assessment of chemical composition is usually based on the absorption differences of chromophores between multiple wavelengths, which heavily increase the complexity and cost of the imaging system. In this study, a new method based on single-wavelength PAI to detect intra-plaque haemorrhages, an important indicator of plaque vulnerability, is developed. The method uses wall filtering based on singular value decomposition. To test the method, a carotid plaque phantom mimicking intra-plaque haemorrhages, lumen and vasa vasorum is designed and imaged at 808nm in vitro. The phantom experiment shows wall filtering using singular value decomposition to be a viable method capable of discriminating signals originating from the lumen, vasa vasorum and intraplaque haemorrhages, allowing for the detection of intra-plaque haemorrhages with single wavelength PAI. This enables new opportunities for PAI of vulnerable carotid plaques with more cost effective and diverse laser sources.

Original languageEnglish
Title of host publicationOpto-Acoustic Methods and Applications in Biophotonics IV
EditorsVasilis Ntziachristos, Roger Zemp
Number of pages3
ISBN (Electronic)9781510628472
ISBN (Print)978-1-5106-2847-2
Publication statusPublished - 19 Jul 2019
EventOpto-Acoustic Methods and Applications in Biophotonics IV 2019 - Munich, Germany
Duration: 24 Jun 201925 Jun 2019

Publication series

NameProceedings of SPIE


ConferenceOpto-Acoustic Methods and Applications in Biophotonics IV 2019


  • Intraplaque haemorrhage
  • Photoacoustic imaging
  • Singular value decomposition
  • intraplaque haemorrhage
  • photoacoustic imaging
  • singular value decomposition


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