Intra-aortic balloon pump support in the isolated beating porcine heart in nonischemic and ischemic pump failure

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Abstract

The blood pressure changes induced by the intra-aortic balloon pump (IABP) are expected to create clinical improvement in terms of coronary perfusion and myocardial oxygen consumption. However, the measured effects reported in literature are inconsistent. The aim of this study was to investigate the influence of ischemia on IABP efficacy in healthy hearts and in shock. Twelve slaughterhouse porcine hearts (hearts 1-12) were connected to an external circulatory system, while physiologic cardiac performance was restored. Different clinical scenarios, ranging from healthy to cardiogenic shock, were simulated by step-wise administration of negative inotropic drugs. In hearts 7-12, severe global myocardial ischemia superimposed upon the decreased contractile states was created. IABP support was applied in all hearts under all conditions. Without ischemia, the IABP induced a mild increase in coronary blood flow and cardiac output. These effects were strongly augmented in the presence of persisting ischemia, where coronary blood flow increased by 49 ± 24% (P 
Original languageEnglish
Pages (from-to)931-938
Number of pages8
JournalArtificial Organs
Volume39
Issue number11
DOIs
Publication statusPublished - Nov 2015

Keywords

  • Intra-aortic balloon pump
  • Isolated beating porcine heart
  • Persistent ischemia

Cite this

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title = "Intra-aortic balloon pump support in the isolated beating porcine heart in nonischemic and ischemic pump failure",
abstract = "The blood pressure changes induced by the intra-aortic balloon pump (IABP) are expected to create clinical improvement in terms of coronary perfusion and myocardial oxygen consumption. However, the measured effects reported in literature are inconsistent. The aim of this study was to investigate the influence of ischemia on IABP efficacy in healthy hearts and in shock. Twelve slaughterhouse porcine hearts (hearts 1-12) were connected to an external circulatory system, while physiologic cardiac performance was restored. Different clinical scenarios, ranging from healthy to cardiogenic shock, were simulated by step-wise administration of negative inotropic drugs. In hearts 7-12, severe global myocardial ischemia superimposed upon the decreased contractile states was created. IABP support was applied in all hearts under all conditions. Without ischemia, the IABP induced a mild increase in coronary blood flow and cardiac output. These effects were strongly augmented in the presence of persisting ischemia, where coronary blood flow increased by 49 ± 24{\%} (P ",
keywords = "Intra-aortic balloon pump, Isolated beating porcine heart, Persistent ischemia",
author = "Stephanie Schampaert and {van Nunen}, Lokien and Nico Pijls and Marcel Rutten and {van Tuijl}, Sjoerd and {van de Vosse}, Frans and {van 't Veer}, Marcel",
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language = "English",
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Intra-aortic balloon pump support in the isolated beating porcine heart in nonischemic and ischemic pump failure. / Schampaert, Stephanie; van Nunen, Lokien; Pijls, Nico; Rutten, Marcel; van Tuijl, Sjoerd; van de Vosse, Frans; van 't Veer, Marcel.

In: Artificial Organs, Vol. 39, No. 11, 11.2015, p. 931-938.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - van Nunen, Lokien

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AU - Rutten, Marcel

AU - van Tuijl, Sjoerd

AU - van de Vosse, Frans

AU - van 't Veer, Marcel

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