Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 286-292 |
| Journal | EuroIntervention |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jul 2015 |
Fingerprint
Keywords
- coronary autoregulation
- intra-aortic balloon pump
- myocardial infarction
- percutaneous coronary intervention
- persistent ischaemia
Cite this
}
Intra-aortic balloon counterpulsation reduces mortality in large anterior myocardial infarction complicated by persistent ischaemia: a CRISP-AMI substudy. / van Nunen, L.X.; van 't Veer, M.; Schampaert, S.; Rutten, M.C.M.; van de Vosse, F.N.; Patel, M.R.; Pijls, N.H.J.
In: EuroIntervention, Vol. 11, No. 3, 07.2015, p. 286-292.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Intra-aortic balloon counterpulsation reduces mortality in large anterior myocardial infarction complicated by persistent ischaemia: a CRISP-AMI substudy
AU - van Nunen, L.X.
AU - van 't Veer, M.
AU - Schampaert, S.
AU - Rutten, M.C.M.
AU - van de Vosse, F.N.
AU - Patel, M.R.
AU - Pijls, N.H.J.
PY - 2015/7
Y1 - 2015/7
N2 - Aims: This substudy investigated IABP support in large STEMI complicated by persistent ischaemia within the original CRISP-AMI trial. Methods and results: Patients were included if the ECG at admission showed summed ST deviation (ΣST-D) ≥15 mm and the ECG post PCI showed poor ST resolution (<50%). Endpoints evaluated were all-cause mortality at six months and the composite endpoint of death, cardiogenic shock or new or worsening heart failure at six months. One hundred and forty-nine patients had ΣST-D ≥15 mm (mean ΣST-D 24±8 mm). Of these patients, 36 (24%) showed poor ST resolution (15 patients in the IABP group; 21 patients in the control group). Mean age was 55±11 years, 89% were male. Mean systolic and diastolic blood pressures were 135±31 mmHg and 83±22 mmHg, respectively. The left anterior descending coronary artery was the infarct-related artery in all cases, primary PCI was successful in 94%. At six months, zero patients in the IABP group died versus five patients in the control group (0% versus 24%; p=0.046). There was a trend towards statistical significance in the composite endpoint (one patient [7%] versus seven patients [33%]; p=0.06). Conclusions: In this substudy, use of IABP was associated with decreased six-month mortality in large STEMI complicated by persistent ischaemia after PCI.
AB - Aims: This substudy investigated IABP support in large STEMI complicated by persistent ischaemia within the original CRISP-AMI trial. Methods and results: Patients were included if the ECG at admission showed summed ST deviation (ΣST-D) ≥15 mm and the ECG post PCI showed poor ST resolution (<50%). Endpoints evaluated were all-cause mortality at six months and the composite endpoint of death, cardiogenic shock or new or worsening heart failure at six months. One hundred and forty-nine patients had ΣST-D ≥15 mm (mean ΣST-D 24±8 mm). Of these patients, 36 (24%) showed poor ST resolution (15 patients in the IABP group; 21 patients in the control group). Mean age was 55±11 years, 89% were male. Mean systolic and diastolic blood pressures were 135±31 mmHg and 83±22 mmHg, respectively. The left anterior descending coronary artery was the infarct-related artery in all cases, primary PCI was successful in 94%. At six months, zero patients in the IABP group died versus five patients in the control group (0% versus 24%; p=0.046). There was a trend towards statistical significance in the composite endpoint (one patient [7%] versus seven patients [33%]; p=0.06). Conclusions: In this substudy, use of IABP was associated with decreased six-month mortality in large STEMI complicated by persistent ischaemia after PCI.
KW - coronary autoregulation
KW - intra-aortic balloon pump
KW - myocardial infarction
KW - percutaneous coronary intervention
KW - persistent ischaemia
U2 - 10.4244/EIJY14M09_10
DO - 10.4244/EIJY14M09_10
M3 - Article
C2 - 25254356
VL - 11
SP - 286
EP - 292
JO - EuroIntervention
JF - EuroIntervention
SN - 1774-024X
IS - 3
ER -