Intra-aortic balloon counterpulsation reduces mortality in large anterior myocardial infarction complicated by persistent ischaemia: a CRISP-AMI substudy

L.X. van Nunen, M. van 't Veer, S. Schampaert, M.C.M. Rutten, F.N. van de Vosse, M.R. Patel, N.H.J. Pijls

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Abstract

Aims: This substudy investigated IABP support in large STEMI complicated by persistent ischaemia within the original CRISP-AMI trial. Methods and results: Patients were included if the ECG at admission showed summed ST deviation (ΣST-D) ≥15 mm and the ECG post PCI showed poor ST resolution (<50%). Endpoints evaluated were all-cause mortality at six months and the composite endpoint of death, cardiogenic shock or new or worsening heart failure at six months. One hundred and forty-nine patients had ΣST-D ≥15 mm (mean ΣST-D 24±8 mm). Of these patients, 36 (24%) showed poor ST resolution (15 patients in the IABP group; 21 patients in the control group). Mean age was 55±11 years, 89% were male. Mean systolic and diastolic blood pressures were 135±31 mmHg and 83±22 mmHg, respectively. The left anterior descending coronary artery was the infarct-related artery in all cases, primary PCI was successful in 94%. At six months, zero patients in the IABP group died versus five patients in the control group (0% versus 24%; p=0.046). There was a trend towards statistical significance in the composite endpoint (one patient [7%] versus seven patients [33%]; p=0.06). Conclusions: In this substudy, use of IABP was associated with decreased six-month mortality in large STEMI complicated by persistent ischaemia after PCI.
Original languageEnglish
Pages (from-to)286-292
JournalEuroIntervention
Volume11
Issue number3
DOIs
Publication statusPublished - Jul 2015

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Counterpulsation
Ischemia
Myocardial Infarction
Mortality
Electrocardiography
Blood Pressure
Control Groups
Cardiogenic Shock
Coronary Vessels
Heart Failure
Arteries

Keywords

  • coronary autoregulation
  • intra-aortic balloon pump
  • myocardial infarction
  • percutaneous coronary intervention
  • persistent ischaemia

Cite this

@article{d7b53040c8294f0e8098955e92747fdd,
title = "Intra-aortic balloon counterpulsation reduces mortality in large anterior myocardial infarction complicated by persistent ischaemia: a CRISP-AMI substudy",
abstract = "Aims: This substudy investigated IABP support in large STEMI complicated by persistent ischaemia within the original CRISP-AMI trial. Methods and results: Patients were included if the ECG at admission showed summed ST deviation (ΣST-D) ≥15 mm and the ECG post PCI showed poor ST resolution (<50{\%}). Endpoints evaluated were all-cause mortality at six months and the composite endpoint of death, cardiogenic shock or new or worsening heart failure at six months. One hundred and forty-nine patients had ΣST-D ≥15 mm (mean ΣST-D 24±8 mm). Of these patients, 36 (24{\%}) showed poor ST resolution (15 patients in the IABP group; 21 patients in the control group). Mean age was 55±11 years, 89{\%} were male. Mean systolic and diastolic blood pressures were 135±31 mmHg and 83±22 mmHg, respectively. The left anterior descending coronary artery was the infarct-related artery in all cases, primary PCI was successful in 94{\%}. At six months, zero patients in the IABP group died versus five patients in the control group (0{\%} versus 24{\%}; p=0.046). There was a trend towards statistical significance in the composite endpoint (one patient [7{\%}] versus seven patients [33{\%}]; p=0.06). Conclusions: In this substudy, use of IABP was associated with decreased six-month mortality in large STEMI complicated by persistent ischaemia after PCI.",
keywords = "coronary autoregulation, intra-aortic balloon pump, myocardial infarction, percutaneous coronary intervention, persistent ischaemia",
author = "{van Nunen}, L.X. and {van 't Veer}, M. and S. Schampaert and M.C.M. Rutten and {van de Vosse}, F.N. and M.R. Patel and N.H.J. Pijls",
year = "2015",
month = "7",
doi = "10.4244/EIJY14M09_10",
language = "English",
volume = "11",
pages = "286--292",
journal = "EuroIntervention",
issn = "1774-024X",
publisher = "EuroPCR",
number = "3",

}

Intra-aortic balloon counterpulsation reduces mortality in large anterior myocardial infarction complicated by persistent ischaemia: a CRISP-AMI substudy. / van Nunen, L.X.; van 't Veer, M.; Schampaert, S.; Rutten, M.C.M.; van de Vosse, F.N.; Patel, M.R.; Pijls, N.H.J.

In: EuroIntervention, Vol. 11, No. 3, 07.2015, p. 286-292.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Intra-aortic balloon counterpulsation reduces mortality in large anterior myocardial infarction complicated by persistent ischaemia: a CRISP-AMI substudy

AU - van Nunen, L.X.

AU - van 't Veer, M.

AU - Schampaert, S.

AU - Rutten, M.C.M.

AU - van de Vosse, F.N.

AU - Patel, M.R.

AU - Pijls, N.H.J.

PY - 2015/7

Y1 - 2015/7

N2 - Aims: This substudy investigated IABP support in large STEMI complicated by persistent ischaemia within the original CRISP-AMI trial. Methods and results: Patients were included if the ECG at admission showed summed ST deviation (ΣST-D) ≥15 mm and the ECG post PCI showed poor ST resolution (<50%). Endpoints evaluated were all-cause mortality at six months and the composite endpoint of death, cardiogenic shock or new or worsening heart failure at six months. One hundred and forty-nine patients had ΣST-D ≥15 mm (mean ΣST-D 24±8 mm). Of these patients, 36 (24%) showed poor ST resolution (15 patients in the IABP group; 21 patients in the control group). Mean age was 55±11 years, 89% were male. Mean systolic and diastolic blood pressures were 135±31 mmHg and 83±22 mmHg, respectively. The left anterior descending coronary artery was the infarct-related artery in all cases, primary PCI was successful in 94%. At six months, zero patients in the IABP group died versus five patients in the control group (0% versus 24%; p=0.046). There was a trend towards statistical significance in the composite endpoint (one patient [7%] versus seven patients [33%]; p=0.06). Conclusions: In this substudy, use of IABP was associated with decreased six-month mortality in large STEMI complicated by persistent ischaemia after PCI.

AB - Aims: This substudy investigated IABP support in large STEMI complicated by persistent ischaemia within the original CRISP-AMI trial. Methods and results: Patients were included if the ECG at admission showed summed ST deviation (ΣST-D) ≥15 mm and the ECG post PCI showed poor ST resolution (<50%). Endpoints evaluated were all-cause mortality at six months and the composite endpoint of death, cardiogenic shock or new or worsening heart failure at six months. One hundred and forty-nine patients had ΣST-D ≥15 mm (mean ΣST-D 24±8 mm). Of these patients, 36 (24%) showed poor ST resolution (15 patients in the IABP group; 21 patients in the control group). Mean age was 55±11 years, 89% were male. Mean systolic and diastolic blood pressures were 135±31 mmHg and 83±22 mmHg, respectively. The left anterior descending coronary artery was the infarct-related artery in all cases, primary PCI was successful in 94%. At six months, zero patients in the IABP group died versus five patients in the control group (0% versus 24%; p=0.046). There was a trend towards statistical significance in the composite endpoint (one patient [7%] versus seven patients [33%]; p=0.06). Conclusions: In this substudy, use of IABP was associated with decreased six-month mortality in large STEMI complicated by persistent ischaemia after PCI.

KW - coronary autoregulation

KW - intra-aortic balloon pump

KW - myocardial infarction

KW - percutaneous coronary intervention

KW - persistent ischaemia

U2 - 10.4244/EIJY14M09_10

DO - 10.4244/EIJY14M09_10

M3 - Article

C2 - 25254356

VL - 11

SP - 286

EP - 292

JO - EuroIntervention

JF - EuroIntervention

SN - 1774-024X

IS - 3

ER -