Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology

M. Beatrijs van der Hout-van der Jagt (Corresponding author), E.J.T. Verweij, Peter Andriessen, Willem P. de Boode, Arend F. Bos, Frank L.M. Delbressine, Alex J. Eggink, Jan Jaap H.M. Erwich, Loe M.G. Feijs, Floris Groenendaal, Boris W.W. Kramer, A. Titia Lely, Rachel F.A.M. Loop, Franziska Neukamp, Wes Onland, Martijn A. Oudijk, Arjan B. te Pas, Irwin K.M. Reiss, Mark Schoberer, Ralph R. ScholtenMarc E.A. Spaanderman, Myrthe van der Ven, Marijn J. Vermeulen, Frans N. van de Vosse, S. Guid Oei

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Liquid-based perinatal life support (PLS) technology will probably be applied in a first-in-human study within the next decade. Research and development of PLS technology should not only address technical issues, but also consider socio-ethical and legal aspects, its application area, and the corresponding design implications. This paper represents the consensus opinion of a group of healthcare professionals, designers, ethicists, researchers and patient representatives, who have expertise in tertiary obstetric and neonatal care, bio-ethics, experimental perinatal animal models for physiologic research, biomedical modeling, monitoring, and design. The aim of this paper is to provide a framework for research and development of PLS technology. These requirements are considering the possible respective user perspectives, with the aim to co-create a PLS system that facilitates physiological growth and development for extremely preterm born infants.

Original languageEnglish
Article number793531
Number of pages8
JournalFrontiers in Pediatrics
Publication statusPublished - 19 Jan 2022


This work was funded in part by the European Union via the Horizon 2020: Future Emerging Topics call (FET Open), Grant EU863087, project PLS.

FundersFunder number
European Union 's Horizon 2020 - Research and Innovation Framework Programme
European Commission
Horizon 2020863087


    • AAPT
    • artificial placenta
    • design implications
    • perinatal life support
    • user perspectives
    • value-sensitive design


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