Interaction of mitochondrial creatine kinase with model membranes

M. Rojo; R. Hovius; R. Demel; T. Wallimann; H.M. Eppenberger; K. Nicolaij

doi:10.1016/0014-5793(91)80374-C

Interaction of mitochondrial creatine kinase with model membranes

M. Rojo, R. Hovius, R. Demel, T. Wallimann, H.M. Eppenberger, K. Nicolaij

Mechanical Engineering

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The interaction of mitochondrial creatine kinase (Mi-CK; EC 2.7.3.2) with phospholipid monolayers and spread mitochondrial membranes at the air/water interface has been investigated. It appeared that Mi-CK penetrated into these monolayers as evidenced by an increase in surface pressure upon incorporation of Mi-CK. The increase in surface pressure was dependent on (1) the amount and (2) the oligometric form of Mi-CK in the subphase, as well as on (3) the initial surface pressure and (4) the phospholipid composition of the monolayer. In this experimental system Mi-CK was able to interact equally well with both inner and outer mitochondrial membranes.

Original language	English
Pages (from-to)	123-129
Number of pages	7
Journal	FEBS Letters
Volume	281
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(91)80374-C
Publication status	Published - 1991

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title = "Interaction of mitochondrial creatine kinase with model membranes",

abstract = "The interaction of mitochondrial creatine kinase (Mi-CK; EC 2.7.3.2) with phospholipid monolayers and spread mitochondrial membranes at the air/water interface has been investigated. It appeared that Mi-CK penetrated into these monolayers as evidenced by an increase in surface pressure upon incorporation of Mi-CK. The increase in surface pressure was dependent on (1) the amount and (2) the oligometric form of Mi-CK in the subphase, as well as on (3) the initial surface pressure and (4) the phospholipid composition of the monolayer. In this experimental system Mi-CK was able to interact equally well with both inner and outer mitochondrial membranes.",

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T1 - Interaction of mitochondrial creatine kinase with model membranes

AU - Rojo, M.

AU - Hovius, R.

AU - Demel, R.

AU - Wallimann, T.

AU - Eppenberger, H.M.

AU - Nicolaij, K.

PY - 1991

Y1 - 1991

N2 - The interaction of mitochondrial creatine kinase (Mi-CK; EC 2.7.3.2) with phospholipid monolayers and spread mitochondrial membranes at the air/water interface has been investigated. It appeared that Mi-CK penetrated into these monolayers as evidenced by an increase in surface pressure upon incorporation of Mi-CK. The increase in surface pressure was dependent on (1) the amount and (2) the oligometric form of Mi-CK in the subphase, as well as on (3) the initial surface pressure and (4) the phospholipid composition of the monolayer. In this experimental system Mi-CK was able to interact equally well with both inner and outer mitochondrial membranes.

AB - The interaction of mitochondrial creatine kinase (Mi-CK; EC 2.7.3.2) with phospholipid monolayers and spread mitochondrial membranes at the air/water interface has been investigated. It appeared that Mi-CK penetrated into these monolayers as evidenced by an increase in surface pressure upon incorporation of Mi-CK. The increase in surface pressure was dependent on (1) the amount and (2) the oligometric form of Mi-CK in the subphase, as well as on (3) the initial surface pressure and (4) the phospholipid composition of the monolayer. In this experimental system Mi-CK was able to interact equally well with both inner and outer mitochondrial membranes.

U2 - 10.1016/0014-5793(91)80374-C

DO - 10.1016/0014-5793(91)80374-C

M3 - Article

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VL - 281

SP - 123

EP - 129

JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

Interaction of mitochondrial creatine kinase with model membranes

Abstract

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