Interaction of mitochondrial creatine kinase with model membranes

M. Rojo, R. Hovius, R. Demel, T. Wallimann, H.M. Eppenberger, K. Nicolaij

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)


The interaction of mitochondrial creatine kinase (Mi-CK; EC with phospholipid monolayers and spread mitochondrial membranes at the air/water interface has been investigated. It appeared that Mi-CK penetrated into these monolayers as evidenced by an increase in surface pressure upon incorporation of Mi-CK. The increase in surface pressure was dependent on (1) the amount and (2) the oligometric form of Mi-CK in the subphase, as well as on (3) the initial surface pressure and (4) the phospholipid composition of the monolayer. In this experimental system Mi-CK was able to interact equally well with both inner and outer mitochondrial membranes.
Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalFEBS Letters
Issue number1-2
Publication statusPublished - 1991


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