Interaction of mitochondrial creatine kinase with model membranes

M. Rojo, R. Hovius, R. Demel, T. Wallimann, H.M. Eppenberger, K. Nicolaij

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Abstract

The interaction of mitochondrial creatine kinase (Mi-CK; EC 2.7.3.2) with phospholipid monolayers and spread mitochondrial membranes at the air/water interface has been investigated. It appeared that Mi-CK penetrated into these monolayers as evidenced by an increase in surface pressure upon incorporation of Mi-CK. The increase in surface pressure was dependent on (1) the amount and (2) the oligometric form of Mi-CK in the subphase, as well as on (3) the initial surface pressure and (4) the phospholipid composition of the monolayer. In this experimental system Mi-CK was able to interact equally well with both inner and outer mitochondrial membranes.
Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalFEBS Letters
Volume281
Issue number1-2
DOIs
Publication statusPublished - 1991

Fingerprint Dive into the research topics of 'Interaction of mitochondrial creatine kinase with model membranes'. Together they form a unique fingerprint.

Cite this