Abstract
| Original language | English |
|---|---|
| Publication status | Published - Nov 2015 |
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Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip. / Eslami Amirabadi, H.; Sahebali, Sh.; Miggiels, A.L.W.; Frimat, J.-Ph.; Luttge, R.; den Toonder, J.
2015.Research output: Contribution to conference › Poster › Academic
TY - CONF
T1 - Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip
AU - Eslami Amirabadi, H.
AU - Sahebali, Sh.
AU - Miggiels, A.L.W.
AU - Frimat, J.-Ph.
AU - Luttge, R.
AU - den Toonder, J.
PY - 2015/11
Y1 - 2015/11
N2 - Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.
AB - Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.
M3 - Poster
ER -