Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip

H. Eslami Amirabadi; Sh. Sahebali; A.L.W. Miggiels; J.-Ph. Frimat; R. Luttge; J. den Toonder

Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip

H. Eslami Amirabadi, Sh. Sahebali, A.L.W. Miggiels, J.-Ph. Frimat, R. Luttge, J. den Toonder

Research output: Contribution to conference › Poster › Academic

96 Downloads (Pure)

Abstract

Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.

Original language	English
Publication status	Published - Nov 2015

Access to Document

eslamint2015Final published version, 367 KB

Fingerprint Dive into the research topics of 'Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip'. Together they form a unique fingerprint.

Cite this

@conference{2aadaa279b5c472ea0c6b99cf43e84a8,

title = "Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip",

abstract = "Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.",

author = "{Eslami Amirabadi}, H. and Sh. Sahebali and A.L.W. Miggiels and J.-Ph. Frimat and R. Luttge and {den Toonder}, J.",

year = "2015",

month = nov,

language = "English",

}

TY - CONF

T1 - Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip

AU - Eslami Amirabadi, H.

AU - Sahebali, Sh.

AU - Miggiels, A.L.W.

AU - Frimat, J.-Ph.

AU - Luttge, R.

AU - den Toonder, J.

PY - 2015/11

Y1 - 2015/11

N2 - Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.

AB - Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.

M3 - Poster

ER -