Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip

H. Eslami Amirabadi, Sh. Sahebali, A.L.W. Miggiels, J.-Ph. Frimat, R. Luttge, J. den Toonder

Research output: Contribution to conferencePosterAcademic

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Abstract

Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.
Original languageEnglish
Publication statusPublished - Nov 2015

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