Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip

H. Eslami Amirabadi, Sh. Sahebali, A.L.W. Miggiels, J.-Ph. Frimat, R. Luttge, J. den Toonder

Research output: Contribution to conference › Poster › Academic

Abstract

Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.
LanguageEnglish
StatePublished - Nov 2015

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Microfluidics
Scaffolds
Assays
Microfabrication
Controllability
Hydrogels
Gels
Fibers

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Eslami Amirabadi, H. ; Sahebali, Sh. ; Miggiels, A.L.W. ; Frimat, J.-Ph. ; Luttge, R. ; den Toonder, J./ Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip.
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abstract = "Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.",
author = "{Eslami Amirabadi}, H. and Sh. Sahebali and A.L.W. Miggiels and J.-Ph. Frimat and R. Luttge and {den Toonder}, J.",
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Eslami Amirabadi, H, Sahebali, S, Miggiels, ALW, Frimat, J-P, Luttge, R & den Toonder, J 2015, 'Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip'.

Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip. / Eslami Amirabadi, H.; Sahebali, Sh.; Miggiels, A.L.W.; Frimat, J.-Ph.; Luttge, R.; den Toonder, J.

2015.

Research output: Contribution to conference › Poster › Academic

TY - CONF

T1 - Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip

AU - Eslami Amirabadi,H.

AU - Sahebali,Sh.

AU - Miggiels,A.L.W.

AU - Frimat,J.-Ph.

AU - Luttge,R.

AU - den Toonder,J.

PY - 2015/11

Y1 - 2015/11

N2 - Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.

AB - Extracellular matrix (ECM), as a bio-chemical and -physical support for cells, is of great importance in cell migration studies. 3D migration studies, compared to 2D cultures, have proven to best represent the in vivo conditions[1]. Hydrogels are usually used in in vitro studies as the 3D ECM. However, the relevance of the architecture and controllability of gels are debatable[2]. Self standing fibrous scaffolds, which more closely mimic the in vivo condition, can be fabricated (by electro-spinning) with different fiber sizes and architecture and from different materials. In addition, microfluidic chips can intrinsically control the biochemical content of the cell micro-environment which is also important for the cell migration. In this project, we have developed a new micro-fabrication method to integrate fibrous scaffolds inside a microfluidic device to study cell migration on a chip.

M3 - Poster

ER -

Eslami Amirabadi H, Sahebali S, Miggiels ALW, Frimat J-P, Luttge R, den Toonder J. Integration of electro-spun scaffolds inside microfluidic chips : towards 3D migration assays on a chip. 2015.

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