Integrating extracellular matrix-mimicking layers in microfluidic devices: More control over the tumor microenvironment

Hossein Eslami Amirabadi, Sheen SahebAli, Jean Philippe Frimat, Regina Luttge, Jaap M.J. den Toonder

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

A challenge in studying cancer invasion is to understand the interaction between cancer cells and the extracellular matrix (ECM). Although the ECM influences cancer invasion, it is still unclear how its properties contribute to the process. Here, we present a new microfabrication method to integrate ECM-mimicking matrix layers between two microchannels. Using this chip, we have observed that the invasion distance of MDA-MB-231 breast cancer cells into 3D Polycaprolactone matrices and the general cell morphology are not affected by the ECM fiber diameter. The cells however produce longer and more protrusions in the matrix with smaller fiber size.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1157-1158
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2017
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAs 2017) - Savannah International Trade & Convention Center 1 International Drive Savannah, Georgia 31402 USA, Savannah, United States
Duration: 22 Oct 201726 Oct 2017
Conference number: 21
http://www.microtasconferences.org/microtas2017/

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAs 2017)
Abbreviated titleMicroTAS 2017
CountryUnited States
CitySavannah
Period22/10/1726/10/17
Internet address

Keywords

  • 3D Matrix Layers
  • Cancer Cell Invasion
  • ECM Architecture
  • Microfabrication
  • Microfluidics

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